MDS-UPDRS 与生活质量的关系：一项涉及 3206 名患者的大型多中心研究。

Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients.

机构信息

Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Dept. of Neurology, University Hospital L. Pasteur, Kosice, Slovak Republic; Centre of Experimental, Translational and Clinical Medicine, Technology and Innovation Park, P. J. Safarik University, Kosice, Slovak Republic.

National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain.

出版信息

Parkinsonism Relat Disord. 2018 Jul;52:83-89. doi: 10.1016/j.parkreldis.2018.03.027. Epub 2018 Mar 28.

DOI:10.1016/j.parkreldis.2018.03.027

PMID:29625875

Abstract

BACKGROUND

The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients.

METHODS

We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items.

RESULTS

A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue.

CONCLUSIONS

This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.

摘要

背景

健康相关生活质量（HRQoL）与 MDS-UPDRS 之间的关系尚未得到充分研究。本研究旨在评估代表性国际 PD 患者队列中所有 MDS-UPDRS 成分与 HRQoL 之间的关系。

方法

我们收集了人口统计学和疾病相关数据以及 MDS-UPDRS 和 PDQ8 量表。使用 PDQ8 与所有 MDS-UPDRS 项目之间的相关性进行数据分析，随后进行了两次分层多元回归，首先是 MDS-UPDRS 各部分的得分与 PDQ8 之间的关系，其次是在第一个回归中与 PDQ8 得分有显著关系的那些部分的各个项目之间的关系。进行 LASSO 回归分析以评估 PDQ8 与所有 MDS-UPDRS 项目之间的关系。

结果

共有 3206 名 PD 患者纳入本研究。在第一次回归分析中，PDQ8 与 MDS-UPDRS 第一部分和第二部分显著相关，但与第三部分和第四部分不相关。在第二个回归模型中，发现第一部分项目疲劳、疼痛、情绪低落、冷漠和第二部分项目穿衣、从事爱好、冻结、言语和震颤对 PDQ8 有显著贡献。在 LASSO 分析中，第一部分的六个项目、第二部分的七个项目、第三部分的三个项目和第四部分的一个项目对 PDQ8 评分有贡献。与模型相关性最强的五个项目是情绪低落、穿衣、冷漠、疼痛和疲劳。