血液系统恶性肿瘤或实体瘤患者的抗感染疫苗接种策略-德国血液学会和肿瘤医学学会传染病工作组（AGIHO）指南（DGHO）。
Anti-infective vaccination strategies in patients with hematologic malignancies or solid tumors-Guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO).
机构信息
Hematology and Oncology Germering, Lehrpraxis der Ludwig-Maximilians-Universität, University of Munich, Munich.
Department of Internal Medicine, Helios University Hospital Wuppertal, Wuppertal.
出版信息
Ann Oncol. 2018 Jun 1;29(6):1354-1365. doi: 10.1093/annonc/mdy117.
Abstract
Infectious complications are a significant cause of morbidity and mortality in patients with malignancies specifically when receiving anticancer treatments. Prevention of infection through vaccines is an important aspect of clinical care of cancer patients. Immunocompromising effects of the underlying disease as well as of antineoplastic therapies need to be considered when devising vaccination strategies. This guideline provides clinical recommendations on vaccine use in cancer patients including autologous stem cell transplant recipients, while allogeneic stem cell transplantation is subject of a separate guideline. The document was prepared by the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) by reviewing currently available data and applying evidence-based medicine criteria.
摘要
感染并发症是恶性肿瘤患者发病率和死亡率的重要原因，尤其是在接受抗癌治疗时。通过疫苗预防感染是癌症患者临床护理的一个重要方面。在制定疫苗接种策略时，需要考虑基础疾病和抗肿瘤治疗的免疫抑制作用。本指南提供了癌症患者（包括自体干细胞移植受者）疫苗使用的临床建议，而异基因干细胞移植则是另一项指南的主题。该文件由德国血液学和肿瘤学学会（DGHO）传染病工作组（AGIHO）编写，方法是审查现有数据并应用循证医学标准。
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