瘙痒的周围和中枢机制。
Peripheral and Central Mechanisms of Itch.
机构信息
The Solomon H. Snyder Department of Neuroscience and the Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Neuron. 2018 May 2;98(3):482-494. doi: 10.1016/j.neuron.2018.03.023.
Abstract
Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a characteristic behavioral response (scratching). Itch interacts with the other sensory modalities at multiple locations, from its initiation in a particular dermatome to its transmission to the brain where it is finally perceived. In this review, we summarize the current understanding of the molecular and neural mechanisms of itch by starting in the periphery, where itch is initiated, and discussing the circuits involved in itch processing in the CNS.
摘要
瘙痒是一种独特的感觉体验，它由外周神经系统 (PNS) 和中枢神经系统 (CNS) 中基因可区分的神经元编码，以引起特征性行为反应（搔抓）。瘙痒在多个部位与其他感觉模式相互作用，从其在特定皮节的起始到其传输到大脑的最终感知。在这篇综述中，我们从瘙痒起始的外周开始，总结瘙痒的分子和神经机制的现有认识，并讨论中枢神经系统中涉及瘙痒处理的回路。
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