可见光光催化二氟烷基化诱导烯丙醇在间歇和连续流动条件下的1,2-杂芳烃迁移
Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow.
作者信息
Wei Xiao-Jing, Noël Timothy
机构信息
Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology , Eindhoven University of Technology , Den Dolech 2 , 5612 AZ Eindhoven , The Netherlands.
出版信息
J Org Chem. 2018 Sep 21;83(18):11377-11384. doi: 10.1021/acs.joc.8b01624. Epub 2018 Jul 27.
A convenient method for the preparation of sp-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.
报道了一种制备富sp杂环的简便方法。该方法包括光催化二氟烷基化诱导的烯丙醇的1,2-杂芳烃迁移。在此，我们首次描述了使用流动化学促进此类迁移反应的优点，包括更短的反应时间、更高的选择性以及扩大化学反应规模的机会。
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