DNA 甲基化年龄-环境影响、健康影响及其在环境流行病学中的作用。
DNA Methylation Age-Environmental Influences, Health Impacts, and Its Role in Environmental Epidemiology.
机构信息
National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Chapel Hill, NC, USA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
出版信息
Curr Environ Health Rep. 2018 Sep;5(3):317-327. doi: 10.1007/s40572-018-0203-2.
PURPOSE OF REVIEW
DNA methylation-based aging biomarkers are valuable tools for evaluating the aging process from a molecular perspective. These epigenetic aging biomarkers can be evaluated across the lifespan and are tissue specific. This review examines the literature relating environmental exposures to DNA methylation-based aging biomarkers and also the literature evaluating these biomarkers as predictors of health outcomes.
RECENT FINDINGS
Multiple studies evaluated the association between air pollution and DNA methylation age and consistently observed that higher exposures are associated with elevated DNA methylation age. Psychosocial exposures, e.g., traumas and adolescent adversity, and infections are also associated with epigenetic aging. DNA methylation age has been repeatedly associated with mortality, cancer, and cognitive impairment. DNA methylation age is responsive to the environment and predictive of health outcomes. Studies are still needed to evaluate whether DNA methylation age acts as a mediator or modifier of environmental health effects and to understand the impact of factors such as race, gender, and genetics.
目的综述
基于 DNA 甲基化的衰老生物标志物是从分子角度评估衰老过程的有价值工具。这些表观遗传衰老生物标志物可以在整个生命周期内进行评估，并且具有组织特异性。本综述探讨了与环境暴露相关的基于 DNA 甲基化的衰老生物标志物的文献，以及评估这些生物标志物作为健康结果预测因子的文献。
最近的发现
多项研究评估了空气污染与基于 DNA 甲基化的衰老生物标志物之间的关联，一致观察到较高的暴露与 DNA 甲基化年龄的升高有关。心理社会因素，如创伤和青少年逆境以及感染也与表观遗传衰老有关。DNA 甲基化年龄与死亡率、癌症和认知障碍反复相关。DNA 甲基化年龄对环境有反应，并可预测健康结果。仍需要研究来评估 DNA 甲基化年龄是否作为环境健康影响的中介或调节剂，以及了解种族、性别和遗传等因素的影响。
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