RNA-RNA 分子间相互作用在 RNP 组装中的新兴作用。
Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies.
机构信息
Department of Biochemistry, University of Colorado, Boulder, CO 80309, USA.
Department of Biochemistry, University of Colorado, Boulder, CO 80309, USA; Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.
出版信息
Cell. 2018 Aug 9;174(4):791-802. doi: 10.1016/j.cell.2018.07.023.
Eukaryotic cells contain large assemblies of RNA and protein, referred to as ribonucleoprotein (RNP) granules, which include cytoplasmic P-bodies, stress granules, and neuronal and germinal granules, as well as nuclear paraspeckles, Cajal bodies, and RNA foci formed from repeat expansion RNAs. Recent evidence argues that intermolecular RNA-RNA interactions play a role in forming and determining the composition of certain RNP granules. We hypothesize that intermolecular RNA-RNA interactions are favored in cells yet are limited by RNA-binding proteins, helicases, and ribosomes, thereby allowing normal RNA function. An over-abundance of intermolecular RNA-RNA interactions may be toxic since perturbations that increase RNA-RNA interactions such as long repeat expansion RNAs, arginine-containing dipeptide repeat polypeptides, and sequestration or loss of abundant RNA-binding proteins can contribute to degenerative diseases.
真核细胞含有大量的 RNA 和蛋白质复合物，称为核糖核蛋白 (RNP) 颗粒，包括细胞质 P 体、应激颗粒、神经元和生殖细胞颗粒，以及核内的核斑、Cajal 体和由重复扩展 RNA 形成的 RNA 焦点。最近的证据表明，分子间的 RNA-RNA 相互作用在形成和确定某些 RNP 颗粒的组成中起作用。我们假设分子间的 RNA-RNA 相互作用在细胞中是有利的，但受到 RNA 结合蛋白、解旋酶和核糖体的限制，从而允许正常的 RNA 功能。过多的分子间 RNA-RNA 相互作用可能是有毒的，因为增加 RNA-RNA 相互作用的扰动，如长重复扩展 RNA、含精氨酸的二肽重复多肽以及丰富的 RNA 结合蛋白的隔离或丢失，可能导致退行性疾病。
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