与合成漱口水相比，草药漱口水在正畸治疗患者中的防菌斑效果：一项随机对照试验。

Anti-plaque Efficacy of Herbal Mouthwashes Compared to Synthetic Mouthwashes in Patients Undergoing Orthodontic Treatment: A Randomised Controlled Trial.

作者信息

Niazi Fayez Hussain, Kamran Muhammed Abdullah, Naseem Mustafa, AlShahrani Ibrahim, Fraz Tayab Raza, Hosein Mervyn

出版信息

Oral Health Prev Dent. 2018;16(5):409-416. doi: 10.3290/j.ohpd.a40983.

DOI:10.3290/j.ohpd.a40983

PMID:30151504

Abstract

PURPOSE

The present study compared the antiplaque effects of two herbal mouthwashes containing Salvadora persica and Azadirachta indica, respectively, with two synthetic mouthwashes containing either chlorhexidine or cetylpyridinium.

MATERIALS AND METHODS

In this triple-blind, randomised controlled trial, 100 patients undergoing orthodontic treatment underwent scaling and polishing at baseline to obtain a plaque score of zero. In the first phase, they were given oral hygiene instructions and were provided with a standard toothpaste to be used twice daily for a period of three weeks. In the second phase, following scaling and polishing, they were randomly allocated to 4 groups according to 4 different types of mouthwash (A: chlorhexidine; B = cetylpyridinium; C = extracts of Salvadora persica miswak; D: extract of Azadirachta indica miswak) along with previously taught toothbrushing protocol for three more weeks. Plaque accumulation was scored three times according to the Modified Bonded Bracket Plaque Index: at the start, after the toothbrush-toothpaste trial, and at the end of mouthwash trial. The paired t-test was used to compare the pre-plaque and post-plaque indices in all groups. Analysis of mean differences of post-plaque indices between and within groups was performed using the post-hoc Tukey test. Qualitative variables were compared by Crosstab.

RESULTS

Eighty participants completed the study - 63 females and 17 males. There was a statistically significant decrease in mean plaque scores after using mouthwashes in all four groups at follow-up when compared to the baseline plaque score (p = 0.001). The greatest reduction of plaque score was found in group C (extract of Salvadora persica) when compared with group A, chlorhexidine (p = 0.016).

CONCLUSION

Compared to other mouthwashes, Salvadora persica miswak-based mouthwash showed a maximum reduction in the plaque scores among orthodontic patients.

摘要

目的

本研究比较了分别含有佩列格里诺木和印楝的两种草本漱口水与含有氯己定或西吡氯铵的两种合成漱口水的抗牙菌斑效果。

材料与方法

在这项三盲随机对照试验中，100名接受正畸治疗的患者在基线时进行了洁治和抛光，以使牙菌斑评分为零。在第一阶段，他们接受了口腔卫生指导，并获得了一种标准牙膏，每天使用两次，为期三周。在第二阶段，在洁治和抛光后，他们根据4种不同类型的漱口水（A：氯己定；B = 西吡氯铵；C = 佩列格里诺木提取物牙刷；D：印楝提取物牙刷）随机分为4组，并按照之前教授的刷牙方法再使用三周。根据改良粘结托槽牙菌斑指数对牙菌斑积聚情况进行三次评分：开始时、牙刷 - 牙膏试验后以及漱口水试验结束时。使用配对t检验比较所有组的菌斑前指数和菌斑后指数。使用事后Tukey检验对组间和组内菌斑后指数的平均差异进行分析。定性变量通过交叉表进行比较。