靶向G蛋白偶联受体进行疼痛管理。
Targeting G protein-coupled receptor for pain management.
作者信息
Li Hongyan, Wang Rong, Lu Yinying, Xu Xuehua, Ni Jiaxiang
机构信息
Department of Pain Management, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
Department of Central Laboratory, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
出版信息
Brain Circ. 2017 Apr-Jun;3(2):109-113. doi: 10.4103/bc.bc_3_17. Epub 2017 Jul 18.
Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. Great progress has been made in understanding the important roles of various G protein-coupled receptors in the regulation of pain transmission. However, many important questions remain uncertain about the precise signal transduction mechanisms. This review focuses opioid receptor and CXC receptor 4 on the effects and mechanisms of pain. Taken together, chemokines and their receptors are potential targets for the development of novel pain management and therapy.
疼痛是一种与实际的或潜在的组织损伤相关的不愉快的感觉和情感体验，或者是以这种损伤来描述的体验。在理解各种G蛋白偶联受体在疼痛传递调节中的重要作用方面已经取得了很大进展。然而，关于精确的信号转导机制，许多重要问题仍然不确定。这篇综述聚焦于阿片受体和CXC受体4在疼痛方面的作用及机制。综上所述，趋化因子及其受体是新型疼痛管理和治疗开发的潜在靶点。
Zotero 插件