当考虑证据生成的速度时，进行活网络荟萃分析是可行的。

Living network meta-analysis was feasible when considering the pace of evidence generation.

机构信息

Centre d'Epidémiologie Clinique, Assistance Publique-Hôpitaux de Paris, Hôpital Hôtel-Dieu, Paris, France; Centre de Recherche Epidémiologie et Statistique Paris Sorbonne Cité, INSERM U1153, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Cochrane France, Paris, France.

出版信息

J Clin Epidemiol. 2019 Apr;108:10-16. doi: 10.1016/j.jclinepi.2018.12.008. Epub 2018 Dec 12.

DOI:10.1016/j.jclinepi.2018.12.008

PMID:30552957

Abstract

OBJECTIVES

The aim of the study was to assess the feasibility of living network meta-analysis (NMA) taking into account the pace of evidence generation across different medical areas.

STUDY DESIGN AND SETTING

We performed a systematic review to identify published NMAs. For each NMA, we calculated the cumulative number of new trials. To assess the feasibility of living NMA, we considered different update frequencies (4, 6, and 12 months), then evaluated the number of new trials to be included at each update in the NMA and the workload percentage for an update relative to the initial NMA.

RESULTS

We identified 77 NMAs covering 17 different medical areas; 60 (78%) had fewer than four new trials included per year, on average, and 5 (7%) had more than seven trials. With an update frequency of 4, 6, and 12 months, the median number of new trials to be included in the NMA was 0 (interquartile range, 0-1), 1 (0-2), and 2 (1-4), respectively, with mean of 4%, 5%, and 11% workload per update, respectively.

CONCLUSION

The workload associated with updating a living NMA represents about one-tenth of the initial workload; therefore, living NMA is manageable.

摘要

目的

本研究旨在评估考虑不同医学领域证据生成速度的实时网络荟萃分析（NMA）的可行性。

研究设计和设置

我们进行了系统评价以识别已发表的 NMA。对于每个 NMA，我们计算了新试验的累积数量。为了评估实时 NMA 的可行性，我们考虑了不同的更新频率（4、6 和 12 个月），然后评估了 NMA 每次更新中要纳入的新试验数量以及相对于初始 NMA 更新的工作量百分比。

结果

我们确定了 77 项涵盖 17 个不同医学领域的 NMA；60 项（78%）平均每年纳入的新试验少于 4 项，5 项（7%）超过 7 项。更新频率为 4、6 和 12 个月时，NMA 中要纳入的新试验的中位数分别为 0（四分位距，0-1）、1（0-2）和 2（1-4），相应的平均更新工作量分别为 4%、5%和 11%。