基于吡咯修饰的罗丹明 6G 腙的比率荧光探针用于溶酶体中 Cu 的成像。
Ratiometric fluorescent probe based on pyrrole-modified rhodamine 6G hydrazone for the imaging of Cu in lysosomes.
机构信息
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo 454000, PR China.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo 454000, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 5;212:121-127. doi: 10.1016/j.saa.2018.12.041. Epub 2018 Dec 27.
A novel rhodamine-based Schiff base derivative was obtained via the simple condensation of substituted formyl-1H-pyrrole and rhodamine 6G hydrazone. Fluorescence resonance energy transfer enabled the subsequent use of the derivative as a naked-eye colorimetric and ratiometric fluorescent sensor for Cu in semi-aqueous solution, and the existence of the morpholine group enabled the further application of the sensor in imaging Cu in the lysosomes of HeLa cells.
一种新型基于罗丹明的席夫碱衍生物通过取代的甲酰基-1H-吡咯和罗丹明 6G 腙的简单缩合反应得到。荧光共振能量转移使得该衍生物随后可以作为半水相溶液中 Cu 的裸眼比色和比率荧光传感器使用，而吗啉基团的存在使得该传感器可以进一步应用于 HeLa 细胞溶酶体中 Cu 的成像。
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