导致干细胞功能衰退的关键年龄相关信号变化。

Key Age-Imposed Signaling Changes That Are Responsible for the Decline of Stem Cell Function.

作者信息

Mehdipour Melod, Liu Yutong, Liu Chao, Kumar Binod, Kim Daehwan, Gathwala Ranveer, Conboy Irina M

机构信息

Bioengineering, Univercity of California Berkeley, Berkeley, CA, USA.

出版信息

Subcell Biochem. 2018;90:119-143. doi: 10.1007/978-981-13-2835-0_5.

DOI:10.1007/978-981-13-2835-0_5

PMID:30779008

Abstract

This chapter analyzes recent developments in the field of signal transduction of ageing with the focus on the age-imposed changes in TGF-beta/pSmad, Notch, Wnt/beta-catenin, and Jak/Stat networks. Specifically, this chapter delineates how the above-mentioned evolutionary-conserved morphogenic signaling pathways operate in young versus aged mammalian tissues, with insights into how the age-specific broad decline of stem cell function is precipitated by the deregulation of these key cell signaling networks. This chapter also provides perspectives onto the development of defined therapeutic approaches that aim to calibrate intensity of the determinant signal transduction to health-youth, thereby rejuvenating multiple tissues in older people.

摘要

本章分析衰老信号转导领域的最新进展，重点关注TGF-β/pSmad、Notch、Wnt/β-连环蛋白和Jak/Stat网络中与衰老相关的变化。具体而言，本章阐述了上述进化保守的形态发生信号通路在年轻和衰老哺乳动物组织中的运作方式，并深入探讨了这些关键细胞信号网络的失调如何导致干细胞功能随年龄增长而普遍下降。本章还展望了特定治疗方法的发展，这些方法旨在将决定性信号转导的强度校准至健康年轻状态，从而使老年人的多个组织恢复活力。