外泌体环状 RNA：癌症治疗的新模式。
Exo-circRNAs: a new paradigm for anticancer therapy.
机构信息
National Clinical Research Center for Geriatrics and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
出版信息
Mol Cancer. 2019 Mar 30;18(1):56. doi: 10.1186/s12943-019-0986-2.
CircRNAs, as new members of long noncoding RNAs, have been the focus of recent investigation. CircRNAs feature a closed continuous loop structure without 5'-3' polarity or a poly A tail. Many studies have reported the potential application of circRNAs in the clinic as new biomarkers and therapeutic targets in different diseases, especially for cancer. Additionally, the exosomes are important vehicles in cell-to-cell communication. And exo-circRNAs are circRNAs in exosomes which can be detected to provide additional evidence for conventional diagnostic methods and can be applied to suppress the malignant progress in cancer. In this review, we describe the biogenesis, characteristics, and functions of circRNAs and exosomes. Specifically, we present a comprehensive update of the promising role of exo-circRNAs in anticancer therapy.
CircRNAs，作为长链非编码 RNA 的新成员，一直是最近研究的焦点。CircRNAs 具有封闭的连续环结构，没有 5'-3'极性或多聚 A 尾。许多研究报道了 circRNAs 在不同疾病中的临床应用作为新型生物标志物和治疗靶点，特别是癌症。此外，外泌体是细胞间通讯的重要载体。而 exo-circRNAs 是外泌体中的 circRNAs，可以检测到它们，为传统诊断方法提供额外的证据，并可应用于抑制癌症中的恶性进展。在这篇综述中，我们描述了 circRNAs 和外泌体的生物发生、特征和功能。具体来说，我们全面介绍了 exo-circRNAs 在抗癌治疗中的有前途的作用。
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