微小 RNA 在肺癌中的作用。
The Roles of MicroRNA in Lung Cancer.
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
出版信息
Int J Mol Sci. 2019 Mar 31;20(7):1611. doi: 10.3390/ijms20071611.
Lung cancer is the most devastating malignancy in the world. Beyond genetic research, epigenomic studies-especially investigations of microRNAs-have grown rapidly in quantity and quality in the past decade. This has enriched our understanding about basic cancer biology and lit up the opportunities for potential therapeutic development. In this review, we summarize the involvement of microRNAs in lung cancer carcinogenesis and behavior, by illustrating the relationship to each cancer hallmark capability, and in addition, we briefly describe the clinical applications of microRNAs in lung cancer diagnosis and prognosis. Finally, we discuss the potential therapeutic use of microRNAs in lung cancer.
肺癌是全球最具破坏性的恶性肿瘤之一。除了基因研究外，过去十年中，表观基因组研究——尤其是 microRNAs 的研究——在数量和质量上都有了快速的发展。这丰富了我们对癌症基础生物学的认识，并为潜在的治疗开发提供了机会。在这篇综述中，我们通过阐述与每个癌症标志功能的关系，总结了 microRNAs 在肺癌发生和行为中的作用，此外，我们还简要描述了 microRNAs 在肺癌诊断和预后中的临床应用。最后，我们讨论了 microRNAs 在肺癌治疗中的潜在应用。
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