基于吡咯烷的衍生物作为锌和铜离子的双功能化学传感器的执行：在生物成像和分子逻辑门中的应用。
Execution of julolidine based derivative as bifunctional chemosensor for Zn and Cu ions: Applications in bio-imaging and molecular logic gate.
机构信息
Supramolecular and Organometallic Chemistry Lab, Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625021, Tamil Nadu, India.
Department of Chemistry, Saraswathi Narayanan College, Perungudi, Madurai 625022, Tamil Nadu, India.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Aug 5;219:33-43. doi: 10.1016/j.saa.2019.04.029. Epub 2019 Apr 16.
A simple julolidine based chemosensor (JT) was designed and synthesized by single condensation step. JT displayed excellent selectivity and sensitivity with on-off responses towards Zn and Cu over other biologically relevant metal ions in aqueous media. Upon addition of Zn ions, JT exhibited a significant blue shift in emission followed by turn-on enhancement while with Cu, the fluorescence intensity of JT was completely vanished. The 1:1 binding affinity between JT and Zn/Cu was proposed by Job's plot analysis. The detection limit for Zn and Cu ions reached at 3.5 × 10 M and 1.46 × 10 M, respectively. The sensing mechanism of JT with Zn/Cu was supported by DFT calculations. Based on photophysical studies and its reversibility environment with EDTA, molecular logic gates were fabricated. Furthermore, JT was successfully established to detect intracellular Zn ions in live cells by turn-on response.
一种基于简单的六氢吡啶的化学传感器（JT）通过单缩合步骤设计和合成。JT 在水相介质中对 Zn 和 Cu 具有开-关响应，表现出对其他生物相关金属离子优异的选择性和灵敏度。加入 Zn 离子后，JT 的发射出现显著的蓝移，随后增强开环响应，而与 Cu 反应时，JT 的荧光强度完全消失。通过 Job 图分析提出了 JT 与 Zn/Cu 的 1:1 结合亲和力。Zn 和 Cu 离子的检测限分别达到 3.5×10-7 M 和 1.46×10-7 M。DFT 计算支持 JT 与 Zn/Cu 的传感机制。基于光物理研究及其与 EDTA 的可逆环境，制造了分子逻辑门。此外，通过开环响应成功建立了 JT 用于检测活细胞内 Zn 离子。
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