RNA Sequencing: A Potentiator of Discovery-based Research.
作者信息
Alexander Michael, Reyfman Paul A
机构信息
Feinberg School of MedicineNorthwestern UniversityChicago, Illinois.
出版信息
Am J Respir Cell Mol Biol. 2019 Nov;61(5):558-559. doi: 10.1165/rcmb.2019-0156ED.
Abstract
摘要
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3
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6
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Thorax. 2016 May;71(5):454-61. doi: 10.1136/thoraxjnl-2015-208123. Epub 2016 Feb 22.
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8
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