癌症干细胞与放射抗性：DNA修复及其他
Cancer Stem Cells and Radioresistance: DNA Repair and Beyond.
作者信息
Schulz Alexander, Meyer Felix, Dubrovska Anna, Borgmann Kerstin
机构信息
OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Laboratory of Radiobiology & Experimental Radiooncology, Department of Radiotherapy and Radiooncology, Center of Oncology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
出版信息
Cancers (Basel). 2019 Jun 21;11(6):862. doi: 10.3390/cancers11060862.
The current preclinical and clinical findings demonstrate that, in addition to the conventional clinical and pathological indicators that have a prognostic value in radiation oncology, the number of cancer stem cells (CSCs) and their inherent radioresistance are important parameters for local control after radiotherapy. In this review, we discuss the molecular mechanisms of CSC radioresistance attributable to DNA repair mechanisms and the development of CSC-targeted therapies for tumor radiosensitization. We also discuss the current challenges in preclinical and translational CSC research including the high inter- and intratumoral heterogeneity, plasticity of CSCs, and microenvironment-stimulated tumor cell reprogramming.
目前的临床前和临床研究结果表明，除了在放射肿瘤学中具有预后价值的传统临床和病理指标外，癌症干细胞（CSC）的数量及其固有的放射抗性是放疗后局部控制的重要参数。在本综述中，我们讨论了归因于DNA修复机制的CSC放射抗性的分子机制以及用于肿瘤放射增敏的CSC靶向治疗的发展。我们还讨论了临床前和转化性CSC研究中当前面临的挑战，包括肿瘤间和肿瘤内的高度异质性、CSC的可塑性以及微环境刺激的肿瘤细胞重编程。
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