腰椎骨矿物质密度高与乳腺癌呈正相关。
High Bone Mineral Density of the Lumbar Spine Is Positively Associated with Breast Cancer.
机构信息
Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Brazil.
Advanced Breast Diagnostic Center, Mastology Program, Hospital das Clínicas, Federal University of Goiás, Brazil.
出版信息
Biomed Res Int. 2019 May 23;2019:8010356. doi: 10.1155/2019/8010356. eCollection 2019.
OBJECTIVE
The objective of this study was to verify possible associations between bone mineral density (BMD) and breast cancer in recently diagnosed women in the Brazilian Mid-west region, considering the menopausal status of patients.
METHODS
A case-control study was conducted with 142 cases of breast cancer and 234 controls matched by for age, body mass index (BMI), and menopausal status (pre- and postmenopause), performed in a university hospital in the Brazilian Mid-west. Lumbar spine (L1-L4), femoral neck, and total femur BMD were measured by the dual-energy X-ray absorptiometry (DXA) method. For association, a logistic regression analysis was used.
RESULTS
Women in the highest lumbar spine BMD quartile presented had a higher chance of developing breast cancer (OR = 2.31; 1.02-5.25; = 0.045), after adjusting for the confounding variables. Nonetheless, there were no statistically significant differences in the association between pre- and postmenopause in that quartile and breast cancer.
CONCLUSIONS
High lumbar spine BMD was positively associated with breast cancer in the total sample. In evaluating the BMD of the femoral neck and total femur, such an association was not observed.
目的
本研究旨在验证巴西中西部地区近期确诊乳腺癌女性的骨密度（BMD）与乳腺癌之间的可能关联，同时考虑患者的绝经状态。
方法
这是一项在巴西中西部一所大学医院进行的病例对照研究，共纳入 142 例乳腺癌患者和 234 例年龄、体重指数（BMI）和绝经状态（绝经前和绝经后）相匹配的对照组。通过双能 X 射线吸收法（DXA）测量腰椎（L1-L4）、股骨颈和全股骨的 BMD。采用逻辑回归分析进行关联分析。
结果
在校正混杂因素后，腰椎 BMD 最高四分位的女性发生乳腺癌的几率更高（OR=2.31；1.02-5.25；P=0.045）。然而，在该四分位中，绝经前和绝经后与乳腺癌之间的关联没有统计学意义。
结论
在总样本中，高腰椎 BMD 与乳腺癌呈正相关。在评估股骨颈和全股骨的 BMD 时，没有观察到这种关联。
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