杆状病毒核衣壳的组装。
Nucleocapsid Assembly of Baculoviruses.
机构信息
College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China.
Joint International Research Laboratory of Agriculture & Agri-Product Safety, Yangzhou University, Yangzhou 225009, China.
出版信息
Viruses. 2019 Jul 1;11(7):595. doi: 10.3390/v11070595.
The baculovirus nucleocapsid is formed through a rod-like capsid encapsulating a genomic DNA molecule of 80~180 kbp. The viral capsid is a large oligomer composed of many copies of various protein subunits. The assembly of viral capsids is a complex oligomerization process. The timing of expression of nucleocapsid-related proteins, transport pathways, and their interactions can affect the assembly process of preformed capsids. In addition, the selection of viral DNA and the injection of the viral genome into empty capsids are the critical steps in nucleocapsid assembly. This paper reviews the replication and recombination of baculovirus DNA, expression and transport of capsid proteins, formation of preformed capsids, DNA encapsulation, and nucleocapsid formation. This review will provide a basis for further study of the nucleocapsid assembly mechanism of baculovirus.
杆状病毒核衣壳通过棒状衣壳将基因组 DNA 分子（大小为 80~180 kbp）包裹形成。病毒衣壳是由许多不同蛋白亚基的拷贝组成的大型寡聚物。病毒衣壳的组装是一个复杂的寡聚化过程。核衣壳相关蛋白的表达时间、运输途径及其相互作用都会影响已形成的衣壳的组装过程。此外，病毒 DNA 的选择和病毒基因组注入空衣壳是核衣壳组装的关键步骤。本文综述了杆状病毒 DNA 的复制和重组、衣壳蛋白的表达和运输、前衣壳的形成、DNA 包裹和核衣壳的形成。这篇综述将为进一步研究杆状病毒核衣壳组装机制提供基础。
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