新抗原质量，而非数量。
Neoantigen quality, not quantity.
机构信息
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London WC1E 6BT, UK.
Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London WC1E 6BT, UK.
出版信息
Sci Transl Med. 2019 Aug 21;11(506). doi: 10.1126/scitranslmed.aax7918.
PMID:31434757
Abstract
Prioritizing expressed clonal neoantigens in genes required for cancer cell survival may reduce the likelihood of resistance to neoantigen therapies.
摘要
优先考虑在肿瘤细胞存活中必需的基因中表达的克隆性新生抗原，可能会降低对新生抗原治疗产生耐药性的可能性。
Zotero 插件