长非编码 RNA（lncRNA）在神经胶质瘤干细胞中的功能作用。
Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells.
机构信息
Department of Neurosurgery, Hunan Cancer Hospital and The Afliated Cancer Hospital of Xiangya School, Central South University, Changsha, Hunan, China (mainland).
出版信息
Med Sci Monit. 2019 Oct 8;25:7567-7573. doi: 10.12659/MSM.916040.
Glioma, the most common and aggressive type of brain tumor, has a poor prognosis. Glioma stem cells (GSCs) are thought to be responsible for glioma genesis, proliferation, resistance to chemoradiotherapy, and recurrence. Long non-coding RNAs (lncRNAs) have been viewed as a prospective novel target in glioma therapy in recent years due to their functional roles in GSC biological processes. However, how lncRNAs interact with GSCs and the underlining mechanisms associated with these interactions are not yet clear. In this review, we briefly illustrate recent advancements in the functional roles of lncRNA and their potential mechanisms in GSCs.
脑胶质瘤是最常见和侵袭性最强的脑肿瘤，预后不良。胶质瘤干细胞（GSCs）被认为是导致脑胶质瘤发生、增殖、对放化疗耐药和复发的原因。近年来，长链非编码 RNA（lncRNA）因其在 GSC 生物学过程中的功能作用，被视为胶质瘤治疗的一个有前途的新靶点。然而，lncRNA 如何与 GSCs 相互作用以及与之相关的潜在机制尚不清楚。在这篇综述中，我们简要说明了 lncRNA 的功能作用及其在 GSCs 中的潜在机制的最新进展。
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