临床分离鲍曼不动杆菌中新型质粒介导的（X5）基因对替加环素、依拉环素和奥马环素的耐药性。
Novel Plasmid-Mediated (X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate.
机构信息
Institute of Clinical Pharmacology, Peking University First Hospital, Beijing, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China.
出版信息
Antimicrob Agents Chemother. 2019 Dec 20;64(1). doi: 10.1128/AAC.01326-19.
Abstract
A novel, plasmid-mediated, high-level tigecycline resistance (X) gene variant, (X5), was detected in a clinical isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The (X5)-containing plasmid could only be transferred to via electrotransformation. This report follows the recent study describing the identification of (X3) and (X4).
摘要
2017 年，在中国的一株临床分离株中检测到一种新型、质粒介导的高水平替加环素耐药（X）基因变体（X5）。Tet(X5)与 Tet(X3)和 Tet(X4)分别具有 84.5%和 90.5%的氨基酸同一性，具有相似的结合位点和类似的四环素亲和力。含有（X5）的质粒只能通过电转化转移到 。本报告遵循最近描述（X3）和（X4）鉴定的研究。
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