通过纳米粒子递送 microRNA。
MicroRNA delivery through nanoparticles.
机构信息
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy; Singapore-MIT Alliance for Research & Technology (SMART), BioSystems and Micromechanics (BioSyM), Singapore, Singapore(3); Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore(3); Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research, Singapore, Singapore(3).
Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.
出版信息
J Control Release. 2019 Nov 10;313:80-95. doi: 10.1016/j.jconrel.2019.10.007. Epub 2019 Oct 14.
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.
微 RNA（miRNAs）在重大疾病的病因学中起着核心作用，因此引起了科学界越来越多的关注。另一方面，纳米颗粒载体为 miRNA 治疗目的的细胞特异性控制递药提供了前所未有的机会。本综述批判性地讨论了纳米颗粒在癌症和神经退行性疾病治疗以及组织再生中递送 miRNA 治疗药物的用途。本文提出了纳米载体设计和表征的新观点，以加速 miRNA-纳米颗粒从基础研究到临床应用的转化。讨论了负载 miRNA 的纳米粒子的工程设计中的主要挑战，并突出了关键的应用实例，以强调它们在有效和个性化药物治疗方面的治疗潜力。
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