在存在PBT2的情况下，对多粘菌素B和黏菌素变得敏感。
Becomes Susceptible to Polymyxin B and Colistin in the Presence of PBT2.
作者信息
Jen Freda E-C, Everest-Dass Arun V, El-Deeb Ibrahim M, Singh Sanjesh, Haselhorst Thomas, Walker Mark J, von Itzstein Mark, Jennings Michael P
机构信息
Institute for Glycomics , Griffith University , Gold Coast Campus , Southport , Queensland 4222 , Australia.
School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre , The University of Queensland , Brisbane , Queensland 4072 , Australia.
出版信息
ACS Infect Dis. 2020 Jan 10;6(1):50-55. doi: 10.1021/acsinfecdis.9b00307. Epub 2019 Nov 11.
() causes the sexually transmitted disease gonorrhea, which has a global incidence of 106 million cases per year. No vaccine is available to prevent the disease, and the emergence of multidrug resistant (MDR) strains makes an immediate public health threat. Here, we show that an ionophore, PBT2, can reverse the intrinsic resistance of to polymyxin B and colistin. These antibiotics administered in combination with PBT2 may be an effective path to treat MDR gonococcal infections.
（某病原体）引发性传播疾病淋病，该病全球每年发病例数达1.06亿例。目前尚无预防该疾病的疫苗，而且多重耐药（MDR）菌株的出现构成了直接的公共卫生威胁。在此，我们表明离子载体PBT2可逆转（某病原体）对多粘菌素B和黏菌素的固有耐药性。这些抗生素与PBT2联合使用可能是治疗多重耐药淋球菌感染的有效途径。
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