两种不同诊断标准下囊性纤维化患者中变应性支气管肺曲霉病的流行率。

Prevalence of allergic bronchopulmonary aspergillosis in cystic fibrosis patients using two different diagnostic criteria.

机构信息

Department of Medical Mycology, School of medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Paediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Eur Ann Allergy Clin Immunol. 2020 May;52(3):104-111. doi: 10.23822/EurAnnACI.1764-1489.121. Epub 2020 May 5.

DOI:10.23822/EurAnnACI.1764-1489.121

PMID:31702121

Abstract

.There are different diagnostic criteria for the diagnosis of Allergic bronchopulmonary aspergillosis (ABPA) in CF patients. In this present study we evaluated the prevalence of ABPA in Iranian CF patients by two more usual diagnostic criteria as ISHAM working criteria (A) and CF Foundation Consensus Conference criteria (B). Eighty-six CF patients were included in the study. All CF patients underwent for Aspergillus skin prick test (AST), Aspergillus-specific IgE (sIgEAf) and Aspergillus-specific IgG (sIgGAf), total IgE. The ABPA prevalence was estimated by two diagnostic criteria, (A) and (B) and compared. Results. The frequency of positive AST, total IgE, sIgEAf and sIgGAf were 47 (54.6%), 9 (10.5%), 42 (48.8%) and 67 (77.9%), respectively. The obtained rate of ABPA prevalence (10.5%) was identical in two diagnostic criteria A and B (kappa value of 1.000). The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence.

摘要

有不同的诊断标准用于诊断 CF 患者中的变应性支气管肺曲霉病（ABPA）。在本研究中，我们通过两个更常用的诊断标准（ISHAM 工作标准（A）和 CF 基金会共识会议标准（B））评估了伊朗 CF 患者中的 ABPA 患病率。86 名 CF 患者被纳入研究。所有 CF 患者均进行了曲霉皮肤点刺试验（AST）、曲霉特异性 IgE（sIgEAf）和曲霉特异性 IgG（sIgGAf）、总 IgE。通过两种诊断标准（A）和（B）评估 ABPA 患病率，并进行比较。结果。阳性 AST、总 IgE、sIgEAf 和 sIgGAf 的频率分别为 47 例（54.6%）、9 例（10.5%）、42 例（48.8%）和 67 例（77.9%）。两种诊断标准 A 和 B 获得的 ABPA 患病率（10.5%）相同（kappa 值为 1.000）。应用的诊断标准对报告的 ABPA 患病率没有显著影响。