长非编码 RNA 在多个调控水平的作用机制和功能。
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels.
机构信息
State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, NO. 61 Daizong Street, Tai'an 271018, Shandong, China.
State Key Laboratory of Cotton Biology, Chinese Academy of Agricultural Sciences Cotton Research Institute, Key Laboratory for Cotton Genetic Improvement, Anyang 45500, Henan, China.
出版信息
Int J Mol Sci. 2019 Nov 8;20(22):5573. doi: 10.3390/ijms20225573.
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways. They play important roles in biological processes such as chromatin remodeling, transcriptional activation, transcriptional interference, RNA processing, and mRNA translation. lncRNAs have important functions in plant growth and development; biotic and abiotic stress responses; and in regulation of cell differentiation, the cell cycle, and the occurrence of many diseases in humans and animals. In this review, we summarize the functions and mechanisms of lncRNAs in plants, humans, and animals at different regulatory levels.
长链非编码 (lnc) RNA 是指长度大于 200nt 的非编码 RNA。lncRNA 主要与 mRNA、DNA、蛋白质和 miRNA 相互作用，从而以多种方式在表观遗传、转录、转录后、翻译和翻译后水平上调节基因表达。它们在染色质重塑、转录激活、转录干扰、RNA 处理和 mRNA 翻译等生物过程中发挥重要作用。lncRNAs 在植物生长发育、生物和非生物胁迫反应以及细胞分化、细胞周期以及人类和动物许多疾病的发生中具有重要功能。在这篇综述中，我们总结了 lncRNA 在植物、人类和动物不同调控水平下的功能和机制。
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