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城市青少年二手烟草烟雾暴露的来源及生物标志物

Sources and Biomarkers of Secondhand Tobacco Smoke Exposure in Urban Adolescents.

作者信息

Nardone Natalie, Jain Shonul, Addo Newton, St Helen Gideon, Jacob Peyton, Benowitz Neal L

机构信息

Division of Cardiology, Department of Medicine, Program in Clinical Pharmacology, University of California San Francisco (N Nardone, N Addo, and G St.Helen).

Department of Pediatrics, University of California San Francisco (S Jain).

出版信息

Acad Pediatr. 2020 May-Jun;20(4):493-500. doi: 10.1016/j.acap.2019.12.006. Epub 2019 Dec 20.

Abstract

OBJECTIVE

In an urban adolescent population, we evaluated sources of exposure to secondhand smoke exposure (SHS), examined differences in exposure by race/ethnicity, age and sex, and determined the relationship between exposure source(s) and the biomarkers cotinine and NNAL.

METHODS

Participants were recruited from a public hospital-based outpatient clinic in San Francisco, CA, USA.

RESULTS

Of a sample of N = 298 adolescents screened, 235 were biologically confirmed to be exposed to tobacco smoke. Of those, N = 16 were active smokers and N = 219 were exposed to SHS; 91 (39%) were heavily SHS exposed (median cotinine = 0.76 ng/mL) and 128 (54%) had light SHS exposure (median cotinine = 0.11 ng/mL). Within those SHS exposed, the most common source of exposure was in a public area. No significant racial/ethnic differences were found, although African American adolescents were more likely to live in a home that allowed smoking. Older adolescents were more likely to be exposed across several difference sources, and females more likely to be exposed in a car and in public areas. Past 7-day exposure in the home, in a car, and current blunt use were significantly related to biomarkers of exposure.

CONCLUSIONS

Urban adolescents are exposed to SHS across a variety of sources. Although exposure in a public area is most common, exposure in the home and in cars significantly influences tobacco biomarker levels. Interventions to reduce exposure would have the greatest impact in this population if they focused on reducing exposure in the home and in cars. History of blunt use is a strong determinant of tobacco exposure.

摘要

目的

在城市青少年人群中,我们评估了二手烟暴露的来源,研究了不同种族/族裔、年龄和性别的暴露差异,并确定了暴露源与可替宁和NNAL生物标志物之间的关系。

方法

研究对象从美国加利福尼亚州旧金山一家公立医院的门诊招募。

结果

在筛查的N = 298名青少年样本中,有235人经生物学确认接触过烟草烟雾。其中,N = 16人为主动吸烟者,N = 219人为二手烟暴露者;91人(39%)二手烟暴露严重(可替宁中位数 = 0.76 ng/mL),128人(54%)二手烟暴露轻微(可替宁中位数 = 0.11 ng/mL)。在这些二手烟暴露者中,最常见的暴露源是公共场所。未发现显著的种族/族裔差异,不过非裔美国青少年更有可能生活在允许吸烟的家庭中。年龄较大的青少年更有可能通过多种不同来源接触二手烟,而女性更有可能在汽车和公共场所接触二手烟。过去7天在家中、汽车中的暴露以及当前吸食大麻与暴露生物标志物显著相关。

结论

城市青少年通过多种来源接触二手烟。虽然在公共场所暴露最为常见,但在家中和汽车中的暴露对烟草生物标志物水平有显著影响。如果干预措施侧重于减少在家中和汽车中的暴露,那么对减少该人群的二手烟暴露将产生最大影响。吸食大麻史是烟草暴露的一个重要决定因素。

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