细胞衰老在虚弱和心血管疾病中的重要性。

The Importance of Cellular Senescence in Frailty and Cardiovascular Diseases.

机构信息

Department of Medicine, Santa Maria della Misericordia Hospital, Section of Gerontology and Geriatrics, University of Perugia, Piazzale Gambuli 1, 06132, Perugia, Italy.

出版信息

Adv Exp Med Biol. 2020;1216:79-86. doi: 10.1007/978-3-030-33330-0_9.

DOI:10.1007/978-3-030-33330-0_9

PMID:31894549

Abstract

Frailty is a complex clinical syndrome, progressively described in the last thirty years, resulting from multiple impairments across many organs and systems and characterized by a reduction in physiological reserves and increased vulnerability to stressors, as well. Cardiovascular diseases (CVDs) are a common health problem in very old populations. Age-related changes occur throughout the body and in all organs, including the cardiovascular system. Cellular senescence links age-related CVDs and frailty by many mechanisms of particular interest in the aging biology and geriatric syndromes. Cellular senescence may represent the pivotal factor with its senescence-associated secretory phenotype (SASP) leading to systemic inflammation. In this context, SASP may represent the key element in the association between aging, frailty and the development of age-related CVDs.

摘要

衰弱是一种复杂的临床综合征，在过去三十年中逐渐被描述，它是由多个器官和系统的多种损伤引起的，并以生理储备减少和对压力源的易感性增加为特征。心血管疾病（CVDs）是非常老年人群中的常见健康问题。与年龄相关的变化发生在全身和所有器官中，包括心血管系统。细胞衰老通过衰老生物学和老年综合征中特别感兴趣的许多机制将与年龄相关的 CVD 和衰弱联系起来。细胞衰老可能是关键因素，其衰老相关分泌表型（SASP）导致全身炎症。在这种情况下，SASP 可能是衰老、衰弱和与年龄相关的 CVD 发展之间关联的关键因素。