在线纯化：促进药物化学中药物合成与工艺开发的关键要素。
In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry.
作者信息
Weeranoppanant Nopphon, Adamo Andrea
机构信息
Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen Road, Muang, Chonburi 02131, Thailand.
School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Wangchan Valley 555 Moo 1 Payupnai, Wangchan, Rayong 21210 Thailand.
出版信息
ACS Med Chem Lett. 2019 Dec 12;11(1):9-15. doi: 10.1021/acsmedchemlett.9b00491. eCollection 2020 Jan 9.
Abstract
In-line purification is an important tool for flow chemistry. It enables effective handling of unstable intermediates and integration of multiple synthetic steps. The integrated flow synthesis is useful for drug synthesis and process development in medicinal chemistry. In this article, we overview current states of in-line purification methods. In particular, we focus on four common methods: scavenger column, distillation, nanofiltration, and extraction. Examples of their applications are provided.
摘要
在线纯化是流动化学的一项重要工具。它能够有效处理不稳定中间体，并整合多个合成步骤。集成流动合成在药物合成和药物化学工艺开发中很有用。在本文中，我们概述了在线纯化方法的当前状态。特别地，我们重点介绍四种常用方法： scavenger柱、蒸馏、纳滤和萃取。并提供了它们的应用实例。
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