癌细胞膜修饰的沸石咪唑酯骨架共递送顺铂和齐墩果酸诱导膀胱癌细胞凋亡并逆转多药耐药性。
Cancer Cell Membrane-Decorated Zeolitic-Imidazolate Frameworks Codelivering Cisplatin and Oleanolic Acid Induce Apoptosis and Reversed Multidrug Resistance on Bladder Carcinoma Cells.
作者信息
Chen Dong, Cai Longbo, Guo Yihong, Chen Junyi, Gao Qiangli, Yang Junxian, Li Yongfa
机构信息
Department of Urology, 2nd Affiliated Hospital of Fujian Medical University, Quanzhou City 362000, Fujian Province, China.
Department of Urology, The Affiliated Puren Hospital of Wuhan University of Science and Technology, No. 1 Benxi Street, the Fourth Jianshe Road, Qingshan District, Wuhan 430080, China.
出版信息
ACS Omega. 2020 Jan 6;5(2):995-1002. doi: 10.1021/acsomega.9b02261. eCollection 2020 Jan 21.
Combination therapy is emerging as a preferable approach in cancer therapy with minimized side effects and elevated performance. Nevertheless, the poor targeting and drug loading of currently available drug delivery systems (DDSs) are the main difficulties to realize preferable combination therapy of cancer. As a result, a cancer cell membrane-decorated zeolitic-imidazolate framework hybrid nanoparticle (HP) was successfully constructed in our study to codeliver cisplatin (DDP) and oleanolic acid (OLA). Our results showed positive results of the platform (HP/DDP/OLA) for the treatment of bladder cancer (SW780). In detail, HP/DDP/OLA could enhance apoptosis while reverse multidrug resistance in SW780 cells than free drugs alone or monodelivery systems, which might be a suitable DDS for codelivery of different drugs with great promise.
联合疗法正逐渐成为癌症治疗中一种更优的方法，其副作用最小且疗效更佳。然而，当前可用的药物递送系统（DDSs）靶向性差和药物负载量低是实现理想的癌症联合治疗的主要困难。因此，在我们的研究中成功构建了一种癌细胞膜修饰的沸石咪唑酯骨架杂化纳米颗粒（HP），用于共递送顺铂（DDP）和齐墩果酸（OLA）。我们的结果显示该平台（HP/DDP/OLA）对膀胱癌（SW780）的治疗有积极效果。具体而言，与单独使用游离药物或单递送系统相比，HP/DDP/OLA可增强SW780细胞的凋亡并逆转多药耐药性，这可能是一种适用于共递送不同药物且前景广阔的DDS。
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