唾液中 2019 新型冠状病毒的持续检测。
Consistent Detection of 2019 Novel Coronavirus in Saliva.
机构信息
State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
出版信息
Clin Infect Dis. 2020 Jul 28;71(15):841-843. doi: 10.1093/cid/ciaa149.
Abstract
The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. Live virus was detected in saliva by viral culture. Saliva is a promising noninvasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection.
摘要
自采集的唾液样本中，91.7%（11/12）的患者可检测到 2019 新型冠状病毒（2019-nCoV）。连续的唾液病毒载量监测通常呈下降趋势。通过病毒培养可在唾液中检测到活病毒。唾液是诊断、监测和控制 2019-nCoV 感染患者感染的一种很有前途的非侵入性标本。
相似文献
1
Consistent Detection of 2019 Novel Coronavirus in Saliva.
Clin Infect Dis. 2020 Jul 28;71(15):841-843. doi: 10.1093/cid/ciaa149.
2
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
Lancet Infect Dis. 2020 May;20(5):565-574. doi: 10.1016/S1473-3099(20)30196-1. Epub 2020 Mar 23.
3
Saliva as a Noninvasive Specimen for Detection of SARS-CoV-2.
J Clin Microbiol. 2020 Jul 23;58(8). doi: 10.1128/JCM.00776-20.
4
Saliva as an Alternate Specimen Source for Detection of SARS-CoV-2 in Symptomatic Patients Using Cepheid Xpert Xpress SARS-CoV-2.
J Clin Microbiol. 2020 Jul 23;58(8). doi: 10.1128/JCM.01109-20.
5
[Not Available].
Rev Med Suisse. 2020 Sep 16;16(706):1726.
6
Sample collection and stabilization from saliva samples for SARS-CoV-2 detection by qPCR.
Biotechniques. 2020 Sep;69(3):237. doi: 10.2144/btn-2020-1001ap.
7
Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated and with Clinical Specimens.
J Clin Microbiol. 2020 Apr 23;58(5). doi: 10.1128/JCM.00310-20.
8
A case report of SARS-CoV-2 confirmed in saliva specimens up to 37 days after onset: Proposal of saliva specimens for COVID-19 diagnosis and virus monitoring.
J Infect Chemother. 2020 Oct;26(10):1086-1089. doi: 10.1016/j.jiac.2020.06.011. Epub 2020 Jun 13.
9
Evaluating the use of posterior oropharyngeal saliva in a point-of-care assay for the detection of SARS-CoV-2.
Emerg Microbes Infect. 2020 Dec;9(1):1356-1359. doi: 10.1080/22221751.2020.1775133.
10
Efficacy of a novel SARS-CoV-2 detection kit without RNA extraction and purification.
Int J Infect Dis. 2020 Sep;98:16-17. doi: 10.1016/j.ijid.2020.06.074. Epub 2020 Jun 26.
引用本文的文献
1
SARS-CoV-2 bioaerosol transmission in experimentally infected American mink.
Sci Rep. 2025 Jul 1;15(1):22270. doi: 10.1038/s41598-025-08111-1.
2
Multi-objective performance assessment of HVAC systems and physical barriers on COVID-19 infection transmission in a high-speed train.
J Build Eng. 2022 Aug 1;53:104544. doi: 10.1016/j.jobe.2022.104544. Epub 2022 Apr 21.
3
Airborne infection risk assessment of COVID-19 in an inpatient department through on-site occupant behavior surveys.
J Build Eng. 2022 Jul 1;51:104255. doi: 10.1016/j.jobe.2022.104255. Epub 2022 Feb 23.
4
Uncovering SARS-CoV-2 Molecular Epidemiology Across the Pandemic Transition: Insights into Transmission in Clinical and Environmental Samples.
Viruses. 2025 May 19;17(5):726. doi: 10.3390/v17050726.
5
Oral hygiene influence on the incidence and severity of oral manifestations in Coronavirus Disease 2019.
BMC Oral Health. 2025 May 21;25(1):755. doi: 10.1186/s12903-025-06075-2.
6
Mucosal immune responses to SARS-CoV-2 infection and COVID-19 vaccination.
Vaccine. 2025 May 22;56:127175. doi: 10.1016/j.vaccine.2025.127175. Epub 2025 Apr 30.
7
Infoveillance of COVID-19 Infections in Dentistry Using Platform X: Descriptive Study.
J Med Internet Res. 2025 Apr 3;27:e54650. doi: 10.2196/54650.
8
Rapid Recovery From SARS-CoV-2 Infection Among Immunocompromised Children Despite Limited Neutralizing Antibody Response: A Virologic and Sero-Immunologic Analysis of a Single-Center Cohort.
J Korean Med Sci. 2025 Mar 31;40(12):e52. doi: 10.3346/jkms.2025.40.e52.
9
Evaluation of Salivary Diagnostics: Applications, Benefits, Challenges, and Future Prospects in Dental and Systemic Disease Detection.
Cureus. 2025 Jan 16;17(1):e77520. doi: 10.7759/cureus.77520. eCollection 2025 Jan.
10
Direct detection and identification of viruses in saliva using a SpecID ionization modified mass spectrometer.
PLoS One. 2025 Feb 7;20(2):e0316368. doi: 10.1371/journal.pone.0316368. eCollection 2025.
本文引用的文献
1
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan.
Emerg Microbes Infect. 2020 Jan 28;9(1):221-236. doi: 10.1080/22221751.2020.1719902. eCollection 2020.
2
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
3
A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Lancet. 2020 Feb 15;395(10223):514-523. doi: 10.1016/S0140-6736(20)30154-9. Epub 2020 Jan 24.
4
Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study.
Clin Microbiol Infect. 2019 Dec;25(12):1539-1545. doi: 10.1016/j.cmi.2019.04.012. Epub 2019 Apr 18.
5
Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study.
Clin Microbiol Infect. 2019 Mar;25(3):372-378. doi: 10.1016/j.cmi.2018.06.009. Epub 2018 Jun 12.
6
Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community.
Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):1081-1086. doi: 10.1073/pnas.1716561115. Epub 2018 Jan 18.
7
Additional molecular testing of saliva specimens improves the detection of respiratory viruses.
Emerg Microbes Infect. 2017 Jun 7;6(6):e49. doi: 10.1038/emi.2017.35.
8
Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques.
J Virol. 2011 Apr;85(8):4025-30. doi: 10.1128/JVI.02292-10. Epub 2011 Feb 2.
9
Detection of SARS-associated coronavirus in throat wash and saliva in early diagnosis.
Emerg Infect Dis. 2004 Jul;10(7):1213-9. doi: 10.3201/eid1007.031113.
10
Coronavirus as a possible cause of severe acute respiratory syndrome.
Lancet. 2003 Apr 19;361(9366):1319-25. doi: 10.1016/s0140-6736(03)13077-2.
Zotero 插件