Chen Y H, Peng J S
Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2020 Feb 25;23(2):I-IV. doi: 10.3760/cma.j.issn.1671-0274.2020.02.001.
The outbreak of the novel coronavirus pneumonia (NCP) has become a public health emergency in China. Chinese authorities and health agencies had devoted great efforts to control this disease. As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. For the patients with gastrointestinal tumors, pre-admission screening should be done in order to rule out NCP. Real-time RT-PCR panel and chest CT scan should be conducted for patients with fever (>37.3℃), travel history to Hubei Province within 14 days, or contact history with residents from Wuhan district within 14 days. Prevention measures for both medical staffs and the screen-negative admitted patients should also be enhanced because false negative is possible. Medical instruments should be properly discarded or disinfected according to standardized procedures established by the local center for disease control and prevention (CDC). Surgical operation should be reduced at a minimal level to prevent cross infection in this special period.Surgical intervention for benign tumor should be postponed. For malignant tumor, multidisciplinary therapy (MDT) is recommended and non-surgical anti-tumor therapy should be selected with higher priority. Neoadjuvant therapy is highly recommended for gastrointestinal cancer at advanced stages that meet the indications of NCCN guideline (gastric cancer T stage ≥ 2/rectal cancer T stage ≥ 3/unresectable colon cancer). Gastric or esophagogastricjunction (EGJ) malignant tumor with obstruction can be managed with gastric tube decompression or stent placement to relieve the symptoms. Transnasal enteral feeding tube intubation/percutaneous endoscopic gastrostomy could be adopted to ensure enteral nutrition supply. For colorectal malignancy with simple intestinal obstruction, stent placement can achieve a high success rate, which not only helps avoid emergency surgery, but also creates a better condition for subsequent surgery. Transcatheter arterial embolization for hemostasis is an alternative choice for gastrointestinal tumor with bleeding. However, emergency operation still must be performed for patients with acute uncontrolled bleeding, obstruction or after other alternative treatment measures fail. All cases with suspicious or confirmed with NCP must be reported to the local CDC department. All invasive intervention must be performed in a designated isolation area. Tertiary prevention measure must be adopted for all anesthetists with additional face mask or medical goggle protection to prevent respiratory droplet transmission. Preventive enterostomy is preferable in lower digestive tract surgery. Thoroughly disinfecting the operating room after surgery is necessary. Fever after surgery must be carefully differentiated whether it's caused by post-surgery abdominal infection/inflammation or NCP. Single-room isolation and related examinations should be performed according to the standard procedures. We believe that with the unprecedentedly joint efforts of doctors and patients, we will eventually win this war against NCP.
新型冠状病毒肺炎(NCP)疫情已在中国演变为一场突发公共卫生事件。中国政府部门和卫生机构已全力以赴防控这一疾病。作为专注于胃肠道肿瘤治疗的外科医生,我们应时刻保持对NCP的防范意识,并将其融入临床实践的每一个细节。对于胃肠道肿瘤患者,入院前应进行筛查以排除NCP。对于发热(>37.3℃)、14天内有湖北省旅行史或14天内有与武汉地区居民接触史的患者,应进行实时逆转录聚合酶链反应检测和胸部CT扫描。由于可能存在假阴性情况,医护人员以及筛查结果为阴性的入院患者的预防措施也应加强。医疗器械应按照当地疾病预防控制中心(CDC)制定的标准化程序妥善丢弃或消毒。在这个特殊时期,应尽量减少手术操作以防止交叉感染。良性肿瘤的手术干预应推迟。对于恶性肿瘤,建议采用多学科治疗(MDT),优先选择非手术抗肿瘤治疗。对于符合美国国立综合癌症网络(NCCN)指南指征(胃癌T分期≥2/直肠癌T分期≥3/不可切除结肠癌)的晚期胃肠道癌,强烈推荐新辅助治疗。对于伴有梗阻的胃或食管胃交界(EGJ)恶性肿瘤,可采用胃管减压或放置支架来缓解症状。可采用鼻肠管插管/经皮内镜下胃造瘘术来确保肠内营养供应。对于单纯性肠梗阻的结直肠癌,放置支架成功率较高,这不仅有助于避免急诊手术,还为后续手术创造更好的条件。经导管动脉栓塞止血是胃肠道肿瘤出血的一种替代选择。然而,对于急性出血无法控制、梗阻或其他替代治疗措施失败的患者,仍必须进行急诊手术。所有疑似或确诊NCP的病例必须上报当地CDC部门。所有侵入性操作必须在指定的隔离区域进行。所有麻醉医生必须采取三级预防措施,额外佩戴面罩或医用护目镜以防止呼吸道飞沫传播。在下消化道手术中,预防性造口术更为可取。术后必须对手术室进行彻底消毒。术后发热必须仔细鉴别是由术后腹部感染/炎症还是NCP引起的。应按照标准程序进行单间隔离和相关检查。我们相信,在医患双方前所未有的共同努力下,我们最终将赢得这场抗击NCP的战争。