G82S RAGE 多态性与阿尔茨海默病有关。

G82S RAGE polymorphism is associated with Alzheimer's disease.

机构信息

Department of Biotechnology, PSG College of Technology, Peelamedu, Coimbatore, Tamil Nadu, 641004, India.

Department of Biotechnology, PSG College of Technology, Peelamedu, Coimbatore, Tamil Nadu, 641004, India,

出版信息

Front Biosci (Elite Ed). 2020 Mar 1;12(1):150-161. doi: 10.2741/E864.

DOI:10.2741/E864

PMID:32114455

Abstract

Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimer's disease (AD) due to its ability to interact with amyloid beta and to elicit an inflammatory response. sRAGE, one of the splice variants of RAGE, has been reported to be a decoy receptor for amyloid beta peptides. The present study addresses the occurrence of G82S RAGE polymorphism in AD, and its association with the expression of sRAGE and amyloid beta load (Aβ peptide). The results indicated that the heterozygous genotype (GS) was distributed more than the wild genotype (GG) in patients with AD. Moreover, in patients with AD, there was decreased expression of sRAGE and increased expression of tRAGE and TNF-α. The data show that G82S RAGE polymorphism is highly associated with the development of AD, with decreased expression of sRAGE and increased expression of tRAGE and TNF-α.

摘要

晚期糖基化终产物受体（RAGE）因其能够与β淀粉样肽相互作用并引发炎症反应而被认为与阿尔茨海默病（AD）的病理生理学有关。RAGE 的剪接变异体之一 sRAGE 被报道为β淀粉样肽的诱饵受体。本研究探讨了 RAGE 基因 G82S 多态性在 AD 中的发生情况，及其与 sRAGE 表达和淀粉样β肽负荷（Aβ肽）的关系。结果表明，AD 患者杂合基因型（GS）的分布多于野生基因型（GG）。此外，在 AD 患者中，sRAGE 的表达降低，而 tRAGE 和 TNF-α的表达增加。数据表明，RAGE 基因 G82S 多态性与 AD 的发生高度相关，sRAGE 的表达降低，tRAGE 和 TNF-α的表达增加。