鱼油和姜黄素补充剂对老年人脑血管功能的影响：一项随机对照试验。

Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial.

作者信息

Kuszewski Julia C, Wong Rachel H X, Wood Lisa G, Howe Peter R C

机构信息

Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.

Clinical Nutrition Research Centre, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia; Institute for Resilient Regions, University of Southern Queensland, Springfield Central, Australia.

出版信息

Nutr Metab Cardiovasc Dis. 2020 Apr 12;30(4):625-633. doi: 10.1016/j.numecd.2019.12.010. Epub 2019 Dec 30.

DOI:10.1016/j.numecd.2019.12.010

PMID:32127335

Abstract

BACKGROUND AND AIMS

Chronic conditions such as obesity, which contribute to endothelial dysfunction in older adults, can cause impairments in cerebrovascular perfusion, which is associated with accelerated cognitive decline. Supplementing the diet with bioactive nutrients that can enhance endothelial function, such as fish oil or curcumin, may help to counteract cerebrovascular dysfunction.

METHODS AND RESULTS

A 16-week double-blind, randomized placebo-controlled trial was undertaken in 152 older sedentary overweight/obese adults (50-80 years, body mass index: 25-40 kg/m) to investigate effects of fish oil (2000 mg docosahexaenoic acid + 400 mg eicosapentaenoic acid/day), curcumin (160 mg/day) or a combination of both on cerebrovascular function (measured by Transcranial Doppler ultrasound), systemic vascular function (blood pressure, heart rate and arterial compliance) and cardiometabolic (fasting glucose and blood lipids) and inflammatory (C-reactive protein) biomarkers. The primary outcome, cerebrovascular responsiveness to hypercapnia, was not affected by the interventions. However, cerebral artery stiffness was significantly reduced in males following fish oil supplementation (P = 0.007). Furthermore, fish oil reduced heart rate (P = 0.038) and serum triglycerides (P = 0.006) and increased HDL cholesterol (P = 0.002). Curcumin did not significantly affect these outcomes either alone or in combination with fish oil.

CONCLUSION

Regular supplementation with fish oil but not curcumin improved biomarkers of cardiovascular and cerebrovascular function. The combined supplementation did not result in additional benefits. Further studies are warranted to identify an efficacious curcumin dose and to characterize (in terms of sex, BMI, cardiovascular and metabolic risk factors) populations whose cerebrovascular and cognitive functions might benefit from either intervention.

CLINICAL TRIAL REGISTRATION

ACTRN12616000732482p.

摘要

背景与目的

肥胖等慢性疾病会导致老年人血管内皮功能障碍，进而引起脑血管灌注受损，这与认知能力加速衰退有关。在饮食中补充能增强血管内皮功能的生物活性营养素，如鱼油或姜黄素，可能有助于对抗脑血管功能障碍。

方法与结果

对152名久坐不动的超重/肥胖老年人（年龄50 - 80岁，体重指数：25 - 40kg/m²）进行了一项为期16周的双盲、随机、安慰剂对照试验，以研究鱼油（每天2000毫克二十二碳六烯酸 + 400毫克二十碳五烯酸）、姜黄素（每天160毫克）或两者组合对脑血管功能（通过经颅多普勒超声测量）、全身血管功能（血压、心率和动脉顺应性）以及心脏代谢（空腹血糖和血脂）和炎症（C反应蛋白）生物标志物的影响。主要结局指标，即脑血管对高碳酸血症的反应性，未受干预措施影响。然而，补充鱼油后男性的脑动脉僵硬度显著降低（P = 0.007）。此外，鱼油降低了心率（P = 0.038）和血清甘油三酯（P = 0.006），并提高了高密度脂蛋白胆固醇（P = 0.002）。姜黄素单独或与鱼油联合使用均未对这些结局产生显著影响。