成纤维细胞生长因子/成纤维细胞生长因子受体（FGF/FGFR）信号通路与多种癌症类型的耐药性有关。
FGF/FGFR signaling pathway involved resistance in various cancer types.
作者信息
Zhou Yangyang, Wu Chengyu, Lu Guangrong, Hu Zijing, Chen Qiuxiang, Du Xiaojing
机构信息
Department of Rheumatology and Immunology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Department of Gastroenterology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical, Wenzhou, Zhejiang 325000, China).
出版信息
J Cancer. 2020 Feb 3;11(8):2000-2007. doi: 10.7150/jca.40531. eCollection 2020.
Resistance becomes major clinical issue in cancer treatment, which strongly limits patients to benefit from oncotherapy. Growing evidences have been indicative of the critical role of fibroblast growth factor (FGF)/receptor (FGFR) signaling played in resistance to oncotherapy. In this review we discussed the underlying mechanisms of FGF/FGFR signaling mediated resistance to chemotherapy, radiotherapy and target therapy in various cancers. Meanwhile, we summarized the reported mechanism of FGF/FGFR inhibitors resistance in cancers.
耐药性成为癌症治疗中的主要临床问题，这严重限制了患者从肿瘤治疗中获益。越来越多的证据表明成纤维细胞生长因子（FGF）/受体（FGFR）信号传导在肿瘤治疗耐药中发挥关键作用。在本综述中，我们讨论了FGF/FGFR信号传导介导的各种癌症对化疗、放疗和靶向治疗耐药的潜在机制。同时，我们总结了癌症中FGF/FGFR抑制剂耐药的报道机制。
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