衰老科学视角下的 COVID-19 死亡率。
A Geroscience Perspective on COVID-19 Mortality.
机构信息
Department of Pathology, University of Washington School of Medicine, Seattle.
Department of Biology, University of Washington, Seattle.
出版信息
J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):e30-e33. doi: 10.1093/gerona/glaa094.
A novel coronavirus, SARS-CoV-2, emerged in December 2019, leading within a few months to a global pandemic. COVID-19, the disease caused by this highly contagious virus, can have serious health consequences, though risks of complications are highly age-dependent. Rates of hospitalization and death are less than 0.1% in children, but increase to 10% or more in older people. Moreover, at all ages, men are more likely than women to suffer serious consequences from COVID-19. These patterns are familiar to the geroscience community. The effects of age and sex on mortality rates from COVID-19 mirror the effects of aging on almost all major causes of mortality. These similarities are explored here, and underscore the need to consider the role of basic biological mechanisms of aging on potential treatment and outcomes of COVID-19.
一种新型冠状病毒，SARS-CoV-2，于 2019 年 12 月出现，在短短几个月内导致了全球大流行。由这种高度传染性病毒引起的 COVID-19 可能会对健康造成严重后果，尽管并发症的风险高度取决于年龄。儿童的住院和死亡率不到 0.1%，但在老年人中增加到 10%或更多。此外，在所有年龄段，男性比女性更有可能因 COVID-19 而遭受严重后果。这些模式在老年科学领域是熟悉的。年龄和性别对 COVID-19 死亡率的影响与衰老对几乎所有主要死亡原因的影响相吻合。这里探讨了这些相似之处，并强调了需要考虑衰老的基本生物学机制对 COVID-19 潜在治疗和结果的作用。
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