严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进入因子与固有免疫基因一起在鼻上皮细胞中高表达。
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
作者信息
Sungnak Waradon, Huang Ni, Bécavin Christophe, Berg Marijn, Queen Rachel, Litvinukova Monika, Talavera-López Carlos, Maatz Henrike, Reichart Daniel, Sampaziotis Fotios, Worlock Kaylee B, Yoshida Masahiro, Barnes Josephine L
机构信息
Wellcome Sanger Institute, Cambridge, UK.
Université Côte d'Azur, CNRS, IPMC, Sophia-Antipolis, France.
出版信息
Nat Med. 2020 May;26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.
Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
摘要
我们通过在来自健康人类供体的多个组织的单细胞RNA测序数据中调查病毒进入相关基因的表达，研究了SARS-CoV-2的潜在嗜性。我们在特定的呼吸道、角膜和肠道上皮细胞中共同检测到这些转录本，这可能解释了SARS-CoV-2传播的高效率。这些基因在鼻上皮细胞中与参与先天免疫的基因共同表达，突出了这些细胞在病毒初始感染、传播和清除中的潜在作用。这项研究为利用来自COVID-19患者的宝贵临床样本进行进一步的研究提供了有用的资源，我们在www.covid19cellatlas.org以全面、开放和用户友好的方式提供了我们的数据。
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