遗传因素与性别在急性疼痛与围术期阿片类药物镇痛中的作用

Genetics and Gender in Acute Pain and Perioperative Opioid Analgesia.

机构信息

Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Room H3580, Stanford, CA 94305, USA.

出版信息

Anesthesiol Clin. 2020 Jun;38(2):341-355. doi: 10.1016/j.anclin.2020.01.003. Epub 2020 Apr 1.

DOI:10.1016/j.anclin.2020.01.003

PMID:32336388

Abstract

Experimental and clinical acute pain research in relation to biological sex and genetics started in the 1980s. Research methods became more powerful and sensitive with the advancement in affordable gene sequencing methods and high-throughput genetic assays. Decades of research has identified several potential pharmaceutical targets, providing insights into future research direction, and understanding of acute pain and opioid analgesic effects in the clinical setting. However, there is insufficient evidence to make generalized recommendations for using genetic tests for clinical practice of acute pain management.

摘要

20 世纪 80 年代开始，与生物性别和遗传学相关的医学急性疼痛的实验和临床研究就已经出现。随着基因测序方法和高通量基因检测技术成本的降低，研究方法也变得更加先进和灵敏。数十年的研究已经确定了一些潜在的药物靶点，为未来的研究方向提供了深入的见解，并有助于理解临床环境中的急性疼痛和阿片类药物的镇痛效果。然而，目前还没有足够的证据支持将基因检测广泛应用于急性疼痛管理的临床实践。