载脂蛋白E中的DNA甲基化：与阿尔茨海默病及心血管健康的关系。
DNA methylation in APOE: The relationship with Alzheimer's and with cardiovascular health.
作者信息
Mur Jure, McCartney Daniel L, Walker Rosie M, Campbell Archie, Bermingham Mairead L, Morris Stewart W, Porteous David J, McIntosh Andrew M, Deary Ian J, Evans Kathryn L, Marioni Riccardo E
机构信息
Department of Psychology University of Edinburgh Edinburgh UK.
Centre for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK.
出版信息
Alzheimers Dement (N Y). 2020 Apr 27;6(1):e12026. doi: 10.1002/trc2.12026. eCollection 2020.
INTRODUCTION
Genetic variation in the apolipoprotein E () gene is associated with Alzheimer's disease (AD) and risk factors for cardiovascular disease (CVD). DNA methylationat has been associated with altered cognition and AD. It is unclear if epigenetic marks could be used for predicting future disease.
METHODS
We assessed blood-based DNA methylation at 13 CpGs in the gene in 5828 participants from the Generation Scotland (GS) cohort. Using linear mixed models regression, we examined the relationships among methylation, cognition, cholesterol, the family history of AD and the risk for CVD.
RESULTS
DNA methylation at two CpGs was associated with the ratio of total cholesterol and HDL cholesterol, but not with cognition, family history of AD, or the risk of CVD.
DISCUSSION
methylation is associated with the levels of blood cholesterol, but there is no evidence for the utility of methylation as a biomarker for predicting AD or CVD.
引言
载脂蛋白E（）基因的遗传变异与阿尔茨海默病（AD）及心血管疾病（CVD）的风险因素相关。基因位点的DNA甲基化与认知改变及AD有关。尚不清楚表观遗传标记是否可用于预测未来疾病。
方法
我们在来自苏格兰一代（GS）队列的5828名参与者中评估了基因中13个CpG位点的血液DNA甲基化情况。使用线性混合模型回归，我们研究了甲基化、认知、胆固醇、AD家族史和CVD风险之间的关系。
结果
两个CpG位点的DNA甲基化与总胆固醇和高密度脂蛋白胆固醇的比值相关，但与认知、AD家族史或CVD风险无关。
讨论
甲基化与血液胆固醇水平相关，但没有证据表明甲基化作为预测AD或CVD的生物标志物具有实用性。
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