在啮齿动物肝脂肪变性的缺血再灌注损伤过程中的病理生理学变化。
Pathophysiological Changes During Ischemia-reperfusion Injury in Rodent Hepatic Steatosis.
机构信息
Laboratory for Research of the Musculoskeletal System "Th. Garofalidis", KAT Hospital, School of Medicine, National & Kapodistrian University of Athens, Kifissia, Greece
Laboratory for Research of the Musculoskeletal System "Th. Garofalidis", KAT Hospital, School of Medicine, National & Kapodistrian University of Athens, Kifissia, Greece.
出版信息
In Vivo. 2020 May-Jun;34(3):953-964. doi: 10.21873/invivo.11863.
BACKGROUND/AIM: Ischemia and reperfusion injuries may produce deleterious effects on hepatic tissue after liver surgery and transplantation. The impact of ischemia-reperfusion injury (IRI) on the liver depends on its substrate, the percentage of liver ischemic tissue subjected to IRI and the ischemia time. The consequences of IRI are more evident in pathologic liver substrates, such as steatotic livers. This review is the result of an extended bibliographic PubMed search focused on the last 20 years. It highlights basic differences encountered during IRI in lean and steatotic livers based on studies using rodent experimental models.
CONCLUSION
The main difference in cell death between lean and steatotic livers is the prevalence of apoptosis in the former and necrosis in the latter. There are also major changes in the effect of intracellular mediators, such as TNFα and IL-1β. Further experimental studies are needed in order to increase current knowledge of IRI effects and relevant mechanisms in both lean and steatotic livers, so that new preventive and therapeutic strategies maybe developed.
背景/目的：肝手术和肝移植后，缺血再灌注损伤可能对肝组织产生有害影响。缺血再灌注损伤（IRI）对肝脏的影响取决于其底物、IRI 所涉及的肝缺血组织的百分比和缺血时间。IRI 的后果在病理性肝底物中更为明显，如脂肪肝。这篇综述是对过去 20 年来扩展文献 PubMed 搜索的结果，它突出了基于使用啮齿动物实验模型的研究，在 lean 和 steatotic 肝脏中遇到的 IRI 基本差异。
结论
lean 和 steatotic 肝脏细胞死亡的主要区别在于前者凋亡为主，后者坏死为主。细胞内介质（如 TNFα 和 IL-1β）的作用也有很大变化。需要进一步的实验研究，以增加对 lean 和 steatotic 肝脏中 IRI 作用和相关机制的现有知识，从而开发新的预防和治疗策略。
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