Section on Clinical, Behavioral, and Outcomes Research, Pediatric, Adolescent, and Young Adult Section, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.
Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Diabetes Technol Ther. 2020 May;22(5):374-382. doi: 10.1089/dia.2019.0350.
: Teens with type 1 diabetes (T1D) often struggle with diabetes self-management, which may lead to suboptimal self-care and worsening hemoglobin A1c (HbA1c). Innovative strategies are needed to improve self-care and protect against glycemic decline, especially during adolescence. We aimed to assess the impact on HbA1c of two interventions, problem-solving and text messaging, in teens with T1D. : In a two-site randomized controlled trial, teens ( = 301) 13-17 years of age with T1D were randomized to one of the four groups using a 2 × 2 factorial design: Teenwork (TW), Text Messaging (Text), TW+Text, or Usual Care. TW intervention included problem-solving aimed at improving T1D self-care for blood glucose (BG) monitoring and insulin bolus dosing. Text intervention involved text reminders to check BG. The primary outcome was change in HbA1c from baseline to 12 months. : At baseline, teens (51% female, 78% white, 59% pump-treated) were (mean ± SD) 15.0 ± 1.3 years, had diabetes duration of 6.5 ± 3.7 years, and HbA1c 8.5% ± 1.1%. There was no significant difference in HbA1c over time by study group. Responsiveness to text reminders by teens in the TEXT and TW+TEXT predicted glycemic benefit; TW did not. : Despite no HbA1c difference by study group, greater response to text message reminders to check BG led to better glycemic control and no deterioration in HbA1c; the problem-solving intervention did not. Given the high penetration of mobile phones and the wide acceptance of text messaging among teens in general, it is encouraging that a text messaging intervention can preserve HbA1c, thus preventing the expected deterioration in glycemic control often seen in teens with T1D.
青少年 1 型糖尿病(T1D)患者在糖尿病自我管理方面常常面临困难,这可能导致自我护理不佳和糖化血红蛋白(HbA1c)恶化。需要创新策略来改善自我护理并防止血糖下降,尤其是在青少年时期。我们旨在评估两种干预措施(问题解决和短信发送)对 T1D 青少年 HbA1c 的影响。
在一项两中心随机对照试验中,将 13-17 岁的 T1D 青少年(n=301)随机分为四组,采用 2×2 析因设计:青少年工作(TW)、短信发送(Text)、TW+Text 或常规护理。TW 干预包括旨在改善 T1D 自我护理以进行血糖(BG)监测和胰岛素推注剂量的问题解决。短信干预包括检查 BG 的短信提醒。主要结局是从基线到 12 个月 HbA1c 的变化。
在基线时,青少年(51%为女性,78%为白人,59%为泵治疗)的(平均±标准差)年龄为 15.0±1.3 岁,糖尿病病程为 6.5±3.7 年,HbA1c 为 8.5%±1.1%。研究组之间 HbA1c 随时间无显著差异。青少年对 TEXT 和 TW+TEXT 中短信提醒的反应性预测了血糖获益;TW 没有。
尽管研究组之间 HbA1c 无差异,但对检查 BG 的短信提醒的反应性更强导致血糖控制更好,HbA1c 无恶化;问题解决干预没有。鉴于手机的高普及率和青少年对短信的广泛接受度,短信干预可以维持 HbA1c,从而防止 T1D 青少年通常出现的预期血糖控制恶化,这令人鼓舞。