钙和磷水平是体重正常患者代谢综合征的其他相关因素之一。
Calcium and Phosphate Levels are Among Other Factors Associated with Metabolic Syndrome in Patients with Normal Weight.
作者信息
Osadnik Kamila, Osadnik Tadeusz, Delijewski Marcin, Lejawa Mateusz, Fronczek Martyna, Reguła Rafał, Gąsior Mariusz, Pawlas Natalia
机构信息
Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
2nd Department of Cardiology and Angiology, Silesian Center for Heart Diseases, Zabrze, TO, Poland.
出版信息
Diabetes Metab Syndr Obes. 2020 Apr 22;13:1281-1288. doi: 10.2147/DMSO.S232497. eCollection 2020.
BACKGROUND AND PURPOSE
We aimed to assess the association between calcium and phosphorous and metabolic syndrome (MetS) in normal-weight individuals.
PATIENTS AND METHODS
The study sample comprised 460 normal-weight (body mass index <25kg/m) adults aged 18-35 years. The diagnosis of MetS was based on the presence of at least two of the following: 1) systolic blood pressure (SBP) ≥130 mmHg or diastolic blood pressure (DBP) ≥85 mmHg, 2) triglycerides (TG) >150 mg/dl, 3) high-density lipoprotein cholesterol (HDL-C) <1 mmol/in men and <1.2 mmol/l in women, 4) total cholesterol (TC) >5.2 mmol/l, and 5) fasting glucose (FBG) >5.55 mmol/l.
RESULTS
Patients with MetS were more often male and slightly older and they had a higher body mass index (BMI) and waist circumference. By definition, patients with MetS had higher levels of BP, GLC, glycated hemoglobin A1c, TC, low-density lipoprotein cholesterol (LDL-C), TG, and apolipoprotein B but significantly lower concentrations of HDL-C and apolipoprotein A. Moreover, subjects with MetS had higher activity of the liver enzymes alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase (GGTP). Higher concentrations of uric acid, creatinine and albumin (ALB) were also observed in subjects with MetS. The factors associated with MetS in the multivariate analysis were higher GGTP activity (OR per 5 unit increase - 1.23 (1.11-1.37); p<0.0001), a higher BMI (OR - 1.28 (1.1-1.52); p=0.003), a higher concentration of calcium (OR per 0.1 mmol/l increase - 1.79 (1.21-2.7); p=0.004), higher ALB levels (OR per 5 g/l increase - 1.76 (1.11-2.95), p=0.02); higher phosphorous levels (OR per 0.1 mmol/l increase - 0.82 (0.67-0.99); p=0.04), and a good household situation (odds ratio (OR) - 0.58 95% confidence interval (CI) (0.31-1.07); p=0.08).
CONCLUSION
Calcium and phosphorus levels are significantly associated with MetS in normal-weight individuals.
背景与目的
我们旨在评估正常体重个体中钙、磷与代谢综合征（MetS）之间的关联。
患者与方法
研究样本包括460名年龄在18 - 35岁的正常体重（体重指数<25kg/m²）成年人。MetS的诊断基于以下至少两项指标：1）收缩压（SBP）≥130 mmHg或舒张压（DBP）≥85 mmHg；2）甘油三酯（TG）>150 mg/dl；3）男性高密度脂蛋白胆固醇（HDL-C）<1 mmol/l，女性<1.2 mmol/l；4）总胆固醇（TC）>5.2 mmol/l；5）空腹血糖（FBG）>5.55 mmol/l。
结果
患有MetS的患者男性居多，年龄稍大，体重指数（BMI）和腰围更高。根据定义，患有MetS的患者血压、血糖、糖化血红蛋白A1c、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、甘油三酯和载脂蛋白B水平较高，但高密度脂蛋白胆固醇和载脂蛋白A浓度显著较低。此外，患有MetS的受试者肝酶丙氨酸转氨酶、碱性磷酸酶和γ-谷氨酰转肽酶（GGTP）活性更高。患有MetS的受试者尿酸、肌酐和白蛋白（ALB）浓度也更高。多变量分析中与MetS相关的因素包括GGTP活性较高（每增加5个单位的比值比（OR） - 1.23（1.11 - 1.37）；p<0.0001）、BMI较高（OR - 1.28（1.1 - 1.52）；p = 0.003）、钙浓度较高（每增加0.1 mmol/l的OR - 1.79（1.21 - 2.7）；p = 0.004）、ALB水平较高（每增加5 g/l的OR - 1.76（1.11 - 2.95），p = 0.02）；磷水平较高（每增加0.1 mmol/l的OR - 0.82（0.67 - 0.99）；p = 0.04），以及良好的家庭状况（比值比（OR） - 0.58，95%置信区间（CI）（0.31 - 1.07）；p = 0.08）。
结论
正常体重个体中钙和磷水平与MetS显著相关。
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