非编码 RNA 通过与细胞信号通路相互作用作为新型生物标志物在结直肠癌进展检测中的作用。

Role of non-coding RNAs as novel biomarkers for detection of colorectal cancer progression through interaction with the cell signaling pathways.

机构信息

Department of Modern Biology, ACECR Institute of Higher Education (Isfahan Branch), Isfahan, Iran.

Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide-University of Seville-CSIC, Sevilla, Spain; Department of Cellular Biology, Genetics and Physiology, Faculty of Science, University of Malaga (UMA), Málaga, Spain.

出版信息

Gene. 2020 Aug 30;753:144796. doi: 10.1016/j.gene.2020.144796. Epub 2020 May 22.

DOI:10.1016/j.gene.2020.144796

PMID:32450203

Abstract

Colorectal cancer (CRC) is one of the most common types of cancer which affects the colon and the rectum. Approximately one third of annual CRC mortality occurs due to the late detection of this type of cancer. Therefore, there is an urgent need for more powerful diagnostic and prognostic tools for identification and treatment of colorectal tumorigenesis. Non-coding RNAs (ncRNAs) have been implicated in the pathology of CRC and also linked to metastasis, proliferation, differentiation, migration, angiogenesis and apoptosis in numerous cancers. Recently, attention has turned towards ncRNAs as specific targets for diagnosis, prognosis and treatment of various types of cancers, including CRC. In this review, we have tried to outline the roles of ncRNAs, and their involvement in signaling pathways responsible for the progression of CRC.

摘要

结直肠癌（CRC）是最常见的癌症类型之一，影响结肠和直肠。每年约有三分之一的 CRC 死亡是由于这种癌症的晚期发现。因此，迫切需要更强大的诊断和预后工具来识别和治疗结直肠肿瘤发生。非编码 RNA（ncRNA）已被牵连到 CRC 的病理学中，并与许多癌症中的转移、增殖、分化、迁移、血管生成和凋亡有关。最近，人们关注到 ncRNA 作为各种类型癌症（包括 CRC）的诊断、预后和治疗的特定靶点。在这篇综述中，我们试图概述 ncRNA 的作用及其在负责 CRC 进展的信号通路中的作用。