英国生物银行 10 万名参与者的影像增强：基本原理、数据采集、管理和未来方向。
The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions.
机构信息
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
出版信息
Nat Commun. 2020 May 26;11(1):2624. doi: 10.1038/s41467-020-15948-9.
UK Biobank is a population-based cohort of half a million participants aged 40-69 years recruited between 2006 and 2010. In 2014, UK Biobank started the world's largest multi-modal imaging study, with the aim of re-inviting 100,000 participants to undergo brain, cardiac and abdominal magnetic resonance imaging, dual-energy X-ray absorptiometry and carotid ultrasound. The combination of large-scale multi-modal imaging with extensive phenotypic and genetic data offers an unprecedented resource for scientists to conduct health-related research. This article provides an in-depth overview of the imaging enhancement, including the data collected, how it is managed and processed, and future directions.
英国生物银行（UK Biobank）是一个基于人群的队列研究，包含 50 万名年龄在 40-69 岁之间的参与者，招募工作于 2006 年至 2010 年期间进行。2014 年，英国生物银行开始了世界上最大规模的多模态成像研究，旨在重新邀请 10 万名参与者进行脑部、心脏和腹部磁共振成像、双能 X 射线吸收测定法和颈动脉超声检查。大规模多模态成像与广泛的表型和遗传数据的结合为科学家进行与健康相关的研究提供了前所未有的资源。本文深入概述了成像增强，包括收集的数据、如何管理和处理这些数据以及未来的发展方向。
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