严重急性呼吸综合征冠状病毒 2 感染：细胞因子在 COVID-19 疾病中的作用。
SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.
机构信息
Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.
Hematology & Hemotherapy Unit. Universitary Hospital Virgen de las Nieves, Granada, Spain.
出版信息
Cytokine Growth Factor Rev. 2020 Aug;54:62-75. doi: 10.1016/j.cytogfr.2020.06.001. Epub 2020 Jun 2.
COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
由 SARS-CoV-2 感染引起的 COVID-19 疾病与一系列生理病理机制有关，这些机制动员了大量生物分子，主要是免疫性质的。在最严重的情况下，主要促炎细胞因子（如 IL-1、IL-6、IL-12、IFN-γ 和 TNF-α）的过度产生会显著恶化预后，这些细胞因子优先靶向肺部组织。本研究回顾了关于需要入住重症监护病房的 COVID-19 患者中不同细胞因子表达变化的已发表数据。细胞因子在这种疾病中的作用及其对结局的影响的数据将支持设计更有效的 COVID-19 管理方法。
Zotero 插件