铁死亡与癌症中脂质代谢的相互作用。
The interaction between ferroptosis and lipid metabolism in cancer.
机构信息
Clinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, 400030, China.
出版信息
Signal Transduct Target Ther. 2020 Jun 30;5(1):108. doi: 10.1038/s41392-020-00216-5.
Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and lipid metabolism in cancer. Their interaction regulates the initiation, development, metastasis, therapy resistance of cancer, as well as the tumor immunity, which offers several potential strategies for cancer treatment. This review is a brief overview of the features characterizing the interaction between ferroptosis and lipid metabolism, and highlights the significance of this interaction in cancer.
铁死亡是一种新的程序性细胞死亡形式，其特征是铁依赖性致命脂质过氧化物的积累。最近的发现集中在铁死亡过程中脂质代谢发生的改变，并为铁死亡与脂质代谢在癌症中的相互作用提供了有趣的见解。它们的相互作用调节癌症的发生、发展、转移、治疗耐药性以及肿瘤免疫，为癌症治疗提供了几种潜在的策略。本文简要概述了铁死亡与脂质代谢相互作用的特征，并强调了这种相互作用在癌症中的重要性。
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