基因组范围的和共转录的 R 环抑制剂。
A genome-wide and cotranscriptional suppressor of R loops.
机构信息
Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
Genes Dev. 2020 Jul 1;34(13-14):863-864. doi: 10.1101/gad.339861.120.
Abstract
R loops arise from hybridization of RNA transcripts with template DNA during transcription. Unrepaired R loops lead to transcription-replication collisions, causing DNA damage and genomic instability. In this issue of , Pérez-Calero and colleagues (pp. 898-912) identify UAP56 as a cotranscriptional RNA-DNA helicase that unwinds R loops. They found that UAP56 helicase activity is required to remove R loops formed from different sources and prevent R-loop accumulation genome-wide at actively transcribed genes.
摘要
R 环是在转录过程中 RNA 转录本与模板 DNA 杂交形成的。未修复的 R 环会导致转录-复制碰撞，从而导致 DNA 损伤和基因组不稳定性。在本期的 中，Pérez-Calero 及其同事（第 898-912 页）鉴定出 UAP56 是一种共转录 RNA-DNA 解旋酶，可解开 R 环。他们发现 UAP56 解旋酶活性对于去除来自不同来源的 R 环以及防止活跃转录基因的全基因组中 R 环积累是必需的。
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