基因多态性对约旦人群感染及三联治疗反应的影响
The Influence of Gene Polymorphisms on Infection and Triple Treatment Response Among Jordanian Population.
作者信息
Shakhatreh Muhamad Ali K, Khabour Omar F, Alzoubi Karem H, BaniHani Mohammed N, Abu-Siniyeh Ahmed, Bashir Nabil A, Sabi Salsabeel H, Mahafdah Mahmoud
机构信息
Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.
Department of Clinical Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Appl Clin Genet. 2020 Jul 2;13:139-145. doi: 10.2147/TACG.S253778. eCollection 2020.
BACKGROUND
() is considered the main cause of gastritis, peptic ulcer and gastric carcinoma in the human populations. infection influences the secretion level of several proinflammatory cytokines including IL-1β, which encoded by the gene.
OBJECTIVE
The current study aimed to investigate whether gene polymorphisms are associated with infection among the Jordanian population and responses to triple therapy.
SUBJECTS AND METHODS
The gastroscopic examination was performed on 412 subjects for infection diagnosis, 257 subjects were found to be infected by (positive cases), whereas 155 subjects were uninfected (negative controls). The gene T-31C and C3954T polymorphisms were genotyped by PCR-RFLP.
RESULTS
It was found that the T-31C polymorphism has a significant association with infection (<0.05), and the TT genotype frequency was significantly higher in infected subjects (50.2%) compared to controls (38.7%). On the other hand, no significant association was detected between C3954T SNPs and infection among the Jordanian population. In addition, none of the examined polymorphisms were found to influence the responses to triple therapy.
CONCLUSION
The gene T-31C SNP might be associated with an enhanced risk of infection among the Jordanian population.
背景
（）被认为是人类胃炎、消化性溃疡和胃癌的主要病因。（）感染会影响包括白细胞介素-1β（IL-1β）在内的几种促炎细胞因子的分泌水平，IL-1β由（）基因编码。
目的
本研究旨在调查（）基因多态性是否与约旦人群中的（）感染及三联疗法反应相关。
对象与方法
对412名受试者进行胃镜检查以诊断（）感染，发现257名受试者感染了（）（阳性病例），而155名受试者未感染（阴性对照）。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）对（）基因T-31C和C3954T多态性进行基因分型。
结果
发现T-31C多态性与（）感染显著相关（<0.05），感染受试者的TT基因型频率（50.2%）显著高于对照组（38.7%）。另一方面，在约旦人群中未检测到C3954T单核苷酸多态性（SNP）与（）感染之间存在显著关联。此外，未发现所检测的多态性影响三联疗法的反应。
结论
（）基因T-31C SNP可能与约旦人群中（）感染风险增加有关。
Zotero 插件