AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo bidea, Edificio 609, 48160, Derio, Bizkaia, Spain.
AZTI, Food Research, Basque Research and Technology Alliance (BRTA), Parque Tecnológico de Bizkaia, Astondo bidea, Edificio 609, 48160, Derio, Bizkaia, Spain.
Food Chem Toxicol. 2020 Nov;145:111682. doi: 10.1016/j.fct.2020.111682. Epub 2020 Aug 15.
Listeria monocytogenes is a well-known pathogen responsible for the severe foodborne disease listeriosis. The control of L. monocytogenes occurrence in seafood products and seafood processing environments is an important challenge for the seafood industry and the public health sector. However, bacteriophage biocontrol shows great potential to be used as safety control measure in seafood. This review provides an update on Listeria-specific bacteriophages, focusing on their application as a safe and natural strategy to prevent L. monocytogenes contamination and growth in seafood products and seafood processing environments. Furthermore, the main properties required from bacteriophages intended to be used as biocontrol tools are summarized and emerging strategies to overcome the current limitations are considered. Also, major aspects relevant for bacteriophage production at industrial scale, their access to the market, as well as the current regulatory status of bacteriophage-based solutions for Listeria biocontrol are discussed.
李斯特菌是一种众所周知的病原体，可导致严重的食源性疾病——李斯特菌病。控制海产品及其加工环境中的李斯特菌的发生，是海产品行业和公共卫生部门面临的一项重要挑战。然而，噬菌体生物防治作为一种安全的控制措施，在海产品中有很大的应用潜力。本综述介绍了特定于李斯特菌的噬菌体，重点介绍了它们作为一种安全和自然的策略，以防止李斯特菌在海产品及其加工环境中的污染和生长。此外，总结了用作生物防治工具的噬菌体所需的主要特性，并考虑了克服当前限制的新兴策略。还讨论了在工业规模上生产噬菌体、噬菌体进入市场的主要方面，以及基于噬菌体的李斯特菌生物防治解决方案的当前监管状况。
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