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西弗吉尼亚州慢性疼痛的阿片类药物处方开具与避免药物转移

West Virginia Opioid Prescribing for Chronic Pain While Avoiding Drug Diversion

作者信息

Dydyk Alexander M., Sizemore Daniel C., Trachsel Lindsay A., Conermann Till, Porter Burdett R.

机构信息

Abrazo Central Campus

WVU Medicine

Abstract

Opioid use and abuse for acute and chronic pain is a significant problem in the United States as well as West Virginia. The rate of overdose-related to the use of illicit opioids has drastically increased in the United States and the epicenter has been West Virginia with the highest overdose rate accounting for 41.5 deaths per 100 000 people among the 33 091 deaths in 2015.  Over one-quarter of United States citizens suffer from chronic pain. It is among the most common complaints seen in an outpatient clinic and in the emergency department. The failure to manage acute and chronic pain appropriately, as well as the possible complication of opioid dependence related to treatment, can result in significant morbidity and mortality. One in five patient complaints in an outpatient clinic is related to pain, with over half of all patients seeing their primary care provider for one pain complaint or another. It is paramount that providers have a firm grasp on the management of patients with chronic pain. As a country, the United States spends well over 100 billion dollars a year on healthcare costs related to pain management and opioid dependence. Pain-related expenses exceed those for the costs of cancer, diabetes, and heart disease combined. How a patient's chronic pain gets managed can have profound and long-lasting effects on a patient's quality of life. The International Association for the Study of Pain defines chronic pain as any pain lasting longer than three months. There are multiple sources of chronic pain. Combination therapy for pain includes both pharmacological therapies and nonpharmacological treatment options. There is a more significant reduction in pain with combination therapy compared to a single treatment alone. Escalation of pharmacological therapy is in a stepwise approach. Comorbid depression and anxiety are widespread in patients with chronic pain. Patients with chronic pain are also at increased risk for suicide. Chronic pain can impact every facet of a patient's life. Thus learning to diagnose and appropriately manage patients experiencing chronic pain is critical. Unfortunately, studies have revealed an inherent lack of education regarding pain management in most medical schools and training programs. The Association of American Medical Colleges recognized the problem and has encouraged schools to commit to opioid-related education and training by incorporating the Centers for Disease Control and Prevention guidelines for prescribing opioids for chronic pain into the medical school curriculum. Appropriate opioid prescribing includes prescribing sufficient opioid medication through regular assessment, treatment planning, and monitoring to provide effective pain control while avoiding addiction, abuse, overdose, diversion, and misuse. To be successful, clinicians must understand appropriate opioid prescribing, assessment, the potential for abuse and addiction, and potential psychological problems. Inappropriate opioid prescribing typically involves not prescribing, under prescribing, overprescribing, or continuing to prescribe opioids when they are no longer effective. The American Society of Addiction Medicine describes addiction as a treatable chronic disease that involves environmental pressures, genetics, an individual's life experiences, and interactions among brain circuits.Individuals that become addicted to opioids or other medications often engage in behaviors that become compulsive and result in dangerous consequences. The American Society of Addiction Medicines notes that while the following should not be used as diagnostic criteria due to variability among addicted individuals, they identify five characteristics of addiction: 1. Craving for drug or positive reward. 2. Dysfunctional emotional response. 3. Failure to recognize significant problems affecting behavior and relationships. 4. Inability to consistently abstain. 5. Impairment in control of behavior. Unfortunately, most health providers' understanding regarding addiction is often confusing, inaccurate, and inconsistent due to the broad range of perspectives of those dealing with patients suffering from addiction. While a knowledge gap is present among healthcare providers, it is equally prevalent in politicians writing laws and law enforcement attempting to enforce the laws they write. Payers are responsible for the expenses associated with the evaluation and treatment of addiction. Persistent lack of education and the use of obsolete terminology continue to contribute to a societal lack of understanding for effectively dealing with the challenges of addiction. In the past, the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders defined "addiction," "substance abuse," and "substance dependence" separately. The result was provider confusion contributed to the under-treatment of pain. Over time, the manual has eliminated these terms and now uses "substance use disorder," ranging from mild to severe. Unfortunately, there are numerous challenges in pain management, such as both underprescribing and overprescribing opioids. The concerns are particularly prominent in patients with chronic pain and have resulted in patients suffering from inadequately treated pain while at the same time there has been a development of concomitant opioid abuse, addiction, diversion, and overdose. As a result, providers are often negatively influenced and fail to deliver appropriate, effective, and safe opioids to patients with chronic pain. Providers have, in the past, been poorly trained and ill-informed in their opioid prescribing. To make the challenges even worse, chronic pain patients often develop opioid tolerance, significant psychological, behavioral, and emotional problems, including anxiety and depression related to under or overprescribing opioids.  Clinicians that prescribe opioids face challenges that involve medical negligence in either failure to provide adequate pain control or risk of licensure or even criminal charges if it is perceived they are involved in drug diversion or misuse. All providers that prescribe opioids need additional education and training to provide the best patient outcomes and avoid the social and legal entanglements associated with over and under-prescribing opioids. There are substantial knowledge gaps around appropriate and inappropriate opioid prescribing, including deficits in understanding current research, legislation, and appropriate prescribing practices. Providers often have knowledge deficits that include: Understanding of addiction. At-risk opioid addiction populations. Prescription vs. non-prescription opioid addiction. The belief that addiction and dependence on opioids is synonymous. The belief that opioid addiction is a psychological problem instead related to a chronic painful disease. With a long history of misunderstanding, poor society, provider education, and inconsistent laws, the prescription of opioids has resulted in significant societal challenges that will only resolve with significant education and training. Abuse - Maladaptive pattern of opioid use for a purpose other than pain relief. Addiction - Compulsive pursuit of a chemical substance to find relief or reward. Dependence - Use of a drug that causes a withdrawal syndrome with cessation or reduction in the amount administered. Diversion - Transfering a controlled substance from an authorized person's use to an unauthorized person's use for distribution or possession. Misuse - Use of a medication in a manner different than how it was prescribed. Pseudo-addiction - Aberrant drug-seeking behavior similar to opioid use disorder driven by a need for relief of pain, resolves with pain control. Tolerance - Adaption to the effect of a drug.

摘要

在美国以及西弗吉尼亚州,使用和滥用阿片类药物治疗急慢性疼痛都是一个重大问题。美国与非法阿片类药物使用相关的过量用药率急剧上升,而西弗吉尼亚州是这一现象的中心,其过量用药率最高,在2015年的33091例死亡中,每10万人中有41.5人死亡。超过四分之一的美国公民患有慢性疼痛。这是门诊诊所和急诊科中最常见的主诉之一。未能妥善处理急慢性疼痛,以及与治疗相关的阿片类药物依赖并发症,可能导致严重的发病率和死亡率。门诊诊所中五分之一的患者主诉与疼痛有关,超过一半的患者因各种疼痛问题就诊于初级保健提供者。提供者必须牢固掌握慢性疼痛患者的管理方法。作为一个国家,美国每年在与疼痛管理和阿片类药物依赖相关的医疗费用上支出超过1000亿美元。与疼痛相关的费用超过了癌症、糖尿病和心脏病费用的总和。患者慢性疼痛的管理方式会对其生活质量产生深远而持久的影响。国际疼痛研究协会将慢性疼痛定义为持续超过三个月的任何疼痛。慢性疼痛有多种来源。疼痛的联合治疗包括药物治疗和非药物治疗选择。与单一治疗相比,联合治疗能更显著地减轻疼痛。药物治疗的升级采用逐步推进的方法。慢性疼痛患者中,共病的抑郁和焦虑很普遍。慢性疼痛患者自杀风险也会增加。慢性疼痛会影响患者生活的方方面面。因此,学会诊断和妥善管理慢性疼痛患者至关重要。不幸的是,研究表明,大多数医学院校和培训项目在疼痛管理方面存在内在的教育缺失。美国医学院协会认识到了这个问题,并鼓励学校将疾病控制与预防中心关于慢性疼痛阿片类药物处方的指南纳入医学院课程,致力于与阿片类药物相关的教育和培训。适当的阿片类药物处方包括通过定期评估、治疗计划和监测来开具足够的阿片类药物,以有效控制疼痛,同时避免成瘾、滥用、过量用药、药物转移和误用。要取得成功,临床医生必须了解适当的阿片类药物处方、评估、滥用和成瘾的可能性以及潜在的心理问题。不适当的阿片类药物处方通常包括不开具、开具不足、开具过量或在阿片类药物不再有效时继续开具。美国成瘾医学协会将成瘾描述为一种可治疗的慢性疾病,涉及环境压力、遗传因素、个人生活经历以及大脑回路之间的相互作用。对阿片类药物或其他药物成瘾的个体通常会表现出强迫性行为,并导致危险后果。美国成瘾医学协会指出,虽然由于成瘾个体之间存在差异,以下内容不应作为诊断标准,但它们确定了成瘾的五个特征:1. 对药物或积极奖励的渴望。2. 功能失调的情绪反应。3. 未能认识到影响行为和人际关系的重大问题。4. 无法持续戒除。5. 行为控制受损。不幸的是,由于处理成瘾患者的人员观点广泛,大多数医疗服务提供者对成瘾的理解往往混乱、不准确且不一致。虽然医疗服务提供者之间存在知识差距,但在制定法律的政治家和试图执行他们所制定法律的执法人员中同样普遍存在。支付方负责与成瘾评估和治疗相关的费用。持续的教育缺失和过时术语的使用继续导致社会对有效应对成瘾挑战缺乏理解。过去,美国精神病学协会的《精神疾病诊断与统计手册》分别定义了“成瘾”“物质滥用”和“物质依赖”。结果导致医疗服务提供者困惑,进而造成疼痛治疗不足。随着时间的推移,该手册已删除了这些术语,现在使用“物质使用障碍”,范围从轻度到重度。不幸的是,疼痛管理存在诸多挑战,如阿片类药物开具不足和开具过量。这些问题在慢性疼痛患者中尤为突出,导致患者疼痛治疗不充分,同时出现了阿片类药物滥用、成瘾、转移和过量用药的情况。因此,医疗服务提供者往往受到负面影响,无法为慢性疼痛患者提供适当、有效和安全的阿片类药物。过去,医疗服务提供者在阿片类药物处方方面培训不足且信息匮乏。更糟糕的是,慢性疼痛患者常出现阿片类药物耐受性,以及严重的心理、行为和情绪问题,包括与阿片类药物开具不足或过量相关的焦虑和抑郁。开具阿片类药物的临床医生面临挑战,包括因未能提供充分的疼痛控制而导致的医疗疏忽,或如果被认为参与药物转移或滥用,可能面临执照吊销甚至刑事指控。所有开具阿片类药物的医疗服务提供者都需要额外的教育和培训,以实现最佳的患者治疗效果,并避免与阿片类药物开具过量和不足相关的社会和法律纠纷。在适当和不适当的阿片类药物处方方面存在大量知识差距,包括对当前研究、立法和适当处方实践的理解不足。医疗服务提供者通常存在知识缺陷,包括:对成瘾的理解。阿片类药物成瘾的高危人群。处方与非处方阿片类药物成瘾。认为阿片类药物成瘾与依赖是同义词。认为阿片类药物成瘾是心理问题而非与慢性疼痛疾病相关。由于长期存在误解、社会认知不足、医疗服务提供者教育欠缺以及法律不一致,阿片类药物处方导致了重大的社会挑战,只有通过大量的教育和培训才能解决。滥用——为缓解疼痛以外的目的而出现的阿片类药物使用适应不良模式。成瘾——对化学物质的强迫性追求以寻求缓解或奖励。依赖——使用某种药物,在停药或减少用药量时会出现戒断综合征。转移——将管制药物从授权人员的使用转移到未经授权人员的使用,用于分发或持有。误用——以与处方不同的方式使用药物。假性成瘾——由缓解疼痛的需求驱动的类似于阿片类药物使用障碍的异常觅药行为,在疼痛得到控制后会缓解。耐受性——对药物作用的适应性变化。

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