SARS-CoV-2 的神经嗜性及其神经病理学改变：与其他冠状病毒的相似性。
Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses.
机构信息
Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, No. 155, North Nanjing Street, Heping District, Shenyang, 110001, Liaoning, PR China.
Institute of Clinical Medicine - Neurology, University of Eastern Finland, Yliopistonranta 1C (PO Box 1627), 70211, Kuopio, Finland; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1C (PO Box 1627), 70211, Kuopio, Finland.
出版信息
Neurosci Biobehav Rev. 2020 Dec;119:184-193. doi: 10.1016/j.neubiorev.2020.10.012. Epub 2020 Oct 19.
A novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly around the world. In addition to fever, cough and shortness of breath, it was confirmed that the patients also have manifestations towards the central nervous system (CNS), especially those critically ill ones. In this review, we will discuss how SARS-CoV-2 gain access to the CNS and the possible consequences. Both SARS-CoV-2 and SARS-CoV-1 in 2002 share the same receptor angiotensin-converting enzyme 2 (ACE2), which can be found in the brain and mediate the disease process. Both direct attack of SARS-CoV-2 and the abnormal immune response in the CNS would contribute to the disease. Also, there is a relationship between SARS-CoV-2 and the occurrence of acute cerebrovascular diseases.
一种新型冠状病毒（SARS-CoV-2）源自中国武汉，并迅速在全球范围内传播。除了发热、咳嗽和呼吸急促外，还证实患者还表现出中枢神经系统（CNS）症状，尤其是重症患者。在这篇综述中，我们将讨论 SARS-CoV-2 如何进入 CNS 以及可能产生的后果。2002 年的 SARS-CoV-2 和 SARS-CoV-1 都使用相同的受体血管紧张素转换酶 2（ACE2），该受体存在于大脑中，并介导疾病过程。SARS-CoV-2 的直接攻击和 CNS 中的异常免疫反应都会导致疾病。此外，SARS-CoV-2 与急性脑血管疾病的发生之间存在关联。
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